■骨质疏松症(OP)通常通过评估骨矿物质密度(BMD)来诊断,它经常导致骨折。这里,我们使用孟德尔随机化(MR)研究了饮食来源的循环抗氧化剂与OP风险之间的因果关系.
■发表的研究用于确定与番茄红素等循环抗氧化剂的绝对水平相关的工具变量,视黄醇,抗坏血酸,和β-胡萝卜素,以及抗坏血酸等抗氧化代谢产物,视黄醇,α-生育酚,和γ-生育酚。结果变量包括骨密度(股骨颈,腰椎,前臂,脚跟,全身,全身(60岁以上),全身(45-60岁),全身(30-45岁),全身(15-30岁),和整体(0-15岁)),骨折(手臂,脊柱,腿,脚跟,和骨质疏松性骨折),和OP。基于单核苷酸多态性(SNP)的数量,选择逆方差加权或Wald比率作为MR分析的主要方法。此外,我们进行了敏感性分析,以确认研究结果的可靠性.
■我们发现视黄醇绝对水平与足跟BMD之间存在因果关系(p=7.6E-05)。固定效应IVW的结果显示绝对视黄醇水平对脚跟BMD的保护作用,每0.1ln转化的视黄醇与足跟BMD增加28%相关(OR:1.28,95%CI:1.13-1.44)。此外,在男性中观察到绝对循环视黄醇水平对脚跟BMD的性别特异性影响。没有发现其他显著的因果关系。
■绝对视黄醇水平与足跟BMD之间存在正的因果关系。在未来的研究以及制定公共卫生政策和OP预防策略时,应考虑我们结果的含义。
UNASSIGNED: Osteoporosis (OP) is typically diagnosed by evaluating bone mineral density (BMD), and it frequently results in
fractures. Here, we investigated the causal relationships between diet-derived circulating antioxidants and the risk of OP using Mendelian randomization (MR).
UNASSIGNED: Published studies were used to identify instrumental variables related to absolute levels of circulating antioxidants like lycopene, retinol, ascorbate, and β-carotene, as well as antioxidant metabolites such as ascorbate, retinol, α-tocopherol, and γ-tocopherol. Outcome variables included BMD (in femoral neck, lumbar spine, forearm, heel, total body, total body (age over 60), total body (age 45-60), total body (age 30-45), total body (age 15-30), and total body (age 0-15)),
fractures (in arm, spine, leg, heel, and osteoporotic
fractures), and OP. Inverse variance weighted or Wald ratio was chosen as the main method for MR analysis based on the number of single nucleotide polymorphisms (SNPs). Furthermore, we performed sensitivity analyses to confirm the reliability of the findings.
UNASSIGNED: We found a causal relationship between absolute retinol levels and heel BMD (p = 7.6E-05). The results of fixed effects IVW showed a protective effect of absolute retinol levels against heel BMD, with per 0.1 ln-transformed retinol being associated with a 28% increase in heel BMD (OR: 1.28, 95% CI: 1.13-1.44). In addition, a sex-specific effect of the absolute circulating retinol levels on the heel BMD has been observed in men. No other significant causal relationship was found.
UNASSIGNED: There is a positive causal relationship between absolute retinol levels and heel BMD. The implications of our results should be taken into account in future studies and in the creation of public health policies and OP prevention tactics.