背景:虽然血清中神经丝轻链(NfL)浓度的增加与几种神经系统疾病的进展有关,它们在一般成年人口中的分布和影响在很大程度上仍未被探索。当前的研究旨在阐明广泛且具有代表性的人群样本中血清NfL水平与神经系统疾病之间的关系。
方法:我们利用了2013-2014年国家健康与营养调查(NHANES)周期中1,751名成年人的信息。我们的分析方法包括逻辑回归,平滑曲线拟合,和亚组分析,以确定血清NfL水平和神经系统疾病之间的潜在相关性,包括抑郁症,严重的听力和视力障碍,中风,主观记忆缺陷,和睡眠问题。
结果:调整混杂因素后,我们发现,较高的血清NfL浓度与抑郁症风险增加显著相关,中风,主观记忆缺陷,和更长的睡眠时间(p<0.05)。亚组分析支持这些发现。此外,BMI显著影响血清NfL水平与主观记忆缺陷之间的关系。
结论:我们的研究表明,较高的血清NfL水平与几种神经系统疾病的风险升高密切相关。这些发现强调了血清NfL作为早期检测和监测神经系统疾病的关键标志物的作用。强调其在临床和公共卫生环境中的重要性。
BACKGROUND: While increased neurofilament light chain (NfL) in serum concentrations are linked to the progression of several neurological conditions, their distribution and implications within the general adult population remain largely unexplored. The current research aims to clarify the relationship between serum NfL levels and neurological disorders in a broad and representative population sample.
METHODS: We utilized information gathered from 1751 adults involved in the 2013-2014 cycle of the National Health and Nutrition Examination Survey . Our analytical approach encompassed logistic regression, smoothed curve fitting, and subgroup analyses to identify potential correlations between serum NfL levels and neurological conditions, such as depression, severe hearing and visual impairments, stroke, subjective memory deficits, and sleep problems.
RESULTS: After adjusting for all confounders, we found that higher serum NfL levels were significantly associated with increased risks of depression, stroke, subjective memory deficits, and longer sleep duration (p < 0.05). Subgroup analyses supported these findings. Additionally, BMI significantly influenced the relationship between serum NfL levels and long-term subjective memory decline.
CONCLUSIONS: Our research shows that higher serum NfL levels are strongly related to an elevated risk for several neurological disorders. These findings highlight the role of serum NfL serving as a critical marker for early detection and monitoring of neurological conditions, emphasizing its importance in both clinical and public health settings.