产妇使用非法药物与出生子女的身体和发育不良结果有关。我们的目标是找出一群药物滥用母亲所生的中国儿童中不同发育问题的发生率，将综合计划中招募的受试者的身体健康和发育结果与综合儿童发展服务（CCDS）进行比较，并研究其关联的潜在因素。
■一项回顾性纵向队列研究，在香港特别行政区地区医院对儿童从出生到5岁的身体和发育结果进行频繁的临床评估。在2008年1月1日至2019年2月28日期间，将123名综合计划中的儿童与214名CCDS中的儿童进行了比较。进行Cox回归分析以确定与发育结果相关的可能因素。
■在129名儿童中检测到发育延迟（38.9%）。CCDS组的认知延迟发生率明显较高（p=<0.001），语言延迟(p=<0.001)，电机延迟(p=<0.001)，社会延迟(p=0.002)，和全局延迟(p=0.002)。关于Cox多元回归分析，集成程序(HRadj0.53，95%C.I.0.34-0.84)，社会支持(HRadj0.45，95%C.I.0.25-0.80)，和产妇在分娩后2年内戒除药物（HRadj0.62，95％C.I.0.40-0.95）是显着的保护因素，而男性（HRadj1.73，95％C.I.1.18-2.54）是一个重要的危险因素。
■CCDS实现了怀孕期间滥用药物的准妈妈的早期参与，与多学科合作的早期综合计划是改善这些弱势儿童发展成果的独立因素。
UNASSIGNED: Maternal illicit drug use is associated with negative physical and developmental outcomes for their born children. We aim to find out the incidence of different developmental problems in a cohort of Chinese children born to drug-abusing mothers, compare the physical health and developmental outcomes of the subjects recruited in the Integrated Program to the Comprehensive Child Development Service (CCDS), and to study the potential factors on their associations.
UNASSIGNED: A retrospective longitudinal cohort study with frequent clinical assessments of the children\'s physical and developmental outcomes in a HKSAR\'s regional hospital from birth until 5 years old. 123 Children in Integrated Program were compared with 214 children in CCDS between 1 January 2008 and 28 February 2019. Cox regression analysis was performed to determine the possible factors associated with the developmental outcomes.
UNASSIGNED: Developmental delay was detected in 129 children (38.9%). CCDS group has significantly higher incidence of cognitive delay (p = < 0.001), language delay (p = < 0.001), motor delay (p = < 0.001), social delay (p = 0.002), and global delay (p = 0.002). On Cox multivariable regression analysis, integrated program (HRadj 0.53, 95% C. I. 0.34-0.84), social support (HRadj 0.45, 95% C.I. 0.25-0.80), and maternal abstinence from drug use up to 2-year post-delivery (HRadj 0.62, 95% C.I. 0.40-0.95) were significant protective factors, while male gender (HRadj 1.73, 95% C.I. 1.18-2.54) was a significant risk factor.
UNASSIGNED: CCDS achieves early engagement of drug-abusing expectant mothers during pregnancy, and an early integrated program with multidisciplinary collaboration was an independent factor in improving the developmental outcomes of these vulnerable children.
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