本研究分析了皮肤科诊所2019年至2020年295例浅表真菌感染的患病率和抗真菌药物敏感性。以皮肤癣菌为主(69.5%),包括毛癣菌(T.)rubrum,T.interdigitale,犬小孢子菌,etal.,其次是念珠菌属。(29.5%),包括念珠菌(C.)白色念珠菌,C.近平滑,和C.glabrata.最常见的感染是甲癣(36.3%),股癣(30.5%),和体癣(18.6%)。SFI类型的分布显示出基于性别的差异,年龄,和季节。常见的抗真菌药,包括特比萘芬,伏立康唑,环吡罗嗪,两性霉素B,伊曲康唑,和酮康唑对皮肤癣菌表现出低的最低抑制浓度(MIC),尤其是特比萘芬,这对当地皮肤癣菌引起的SFI是有效的。念珠菌属。菌株通常对5-氟胞嘧啶和两性霉素B敏感或归类为野生型,伊曲康唑的92.0%为野生型。然而,在小比例的白色念珠菌和近平滑念珠菌菌株中观察到对氟康唑和伏立康唑的抗性。耐药念珠菌的出现强调了谨慎使用抗真菌药物和持续监测的重要性。
我们的研究分析了太原地区295例浅表真菌感染,位于中国北方。皮肤癣菌和念珠菌。是主要的病原体,对抗真菌药具有不同的敏感性。结果加深了我们的理解,强调谨慎的药物使用和监督。
This study analyzed the prevalence and antifungal susceptibility of superficial fungal infections in 295 cases from 2019 to 2020 at a dermatology clinic. Dermatophytes were the predominant pathogens (69.5%), including Trichophytonrubrum, T. interdigitale, Microsporum canis, et al., followed by Candida spp. (29.5%), including Candidaalbicans, Ca. parapsilosis, and Ca. glabrata. The most common infections were onychomycosis (36.3%), tinea cruris (30.5%), and tinea corporis (18.6%). The distribution of SFI types showed variations based on gender, age, and season. Common antifungal agents, including terbinafine, voriconazole, ciclopiroxamine, amphotericin B, itraconazole, and ketoconazole have exhibited low minimum inhibitory concentrations against dermatophytes, especially terbinafine, which has been potent against superficial fungal infections caused by dermatophytes in the local area. Candida spp. strains were generally susceptible or classified as wild-type to 5-flucytosine and amphotericin B, with 92.0% being wild-type for itraconazole. However, resistance to fluconazole and voriconazole was observed in a small percentage of Ca. albicans and Ca. parapsilosis strains. The emergence of drug-resistant Candida underscores the importance of prudent antifungal use and continuous surveillance.
Our study analyzed 295 cases of superficial fungal infections in Taiyuan, located in Northern
China. Dermatophytes and Candida spp. were primary pathogens, with varied susceptibilities to antifungals. Results deepen our understanding, emphasizing prudent drug use and surveillance.