未经证实:促纤维化小圆细胞瘤(DSRCT)是一种罕见的,侵略性,一个单独的临床病理实体的间充质恶性肿瘤。它对年轻人有偏爱,没有任何种族偏好的证据.目前DSRCT的诊断金标准包括组织病理学,免疫组织化学,和细胞遗传学研究,以确认可变的表型表达和特征性染色体易位。
未经证实:一名65岁男子出现腹部肿块感和不完全性肠梗阻。除碳水化合物抗原外,初始实验室测试均在正常范围内。对比增强CT显示,在中腹壁和下腹壁的大网膜区域占据了质量混杂密度。对图像进行3D重建以阐明肿瘤与结肠之间的关系,并通过结肠镜检查进行确认。手术后,免疫组织化学和荧光原位杂交(FISH)显示EWSR1-WT1基因在22q12重排,证实了纤维增生性小圆细胞肿瘤的诊断。
未经批准:与DSRCT对年轻人的偏爱不同,在我们的病例中,患者是一名65岁的男性,其巨大的肿块累及横结肠和膀胱。
UNASSIGNED: Desmoplastic small round cell tumor (
DSRCT) is a rare, aggressive, mesenchymal malignancy of a separate clinicopathological entity. It has a predilection for young men, with no evidence of any ethnic predilection. The current diagnostic gold standard for
DSRCT includes histopathologic, immunohistochemical, and cytogenetic studies in order to confirm the variable phenotypic expression and characteristic chromosomal translocation.
UNASSIGNED: A 65-year-old man presented with a sensation of an abdominal mass and a presentation of an incomplete bowel obstruction. Initial lab tests were in the normal range except for carbohydrate antigen. Contrast-enhanced CT showed that a large, mass-confounding density was occupied in the omentum majus area of the middle and lower abdominal wall. A 3D reconstruction of the images was performed to clarify the relationship between the tumor and the colon and was confirmed by a colonoscopy. After surgery, immunohistochemistry and fluorescence in situ hybridization (FISH) revealed EWSR1-WT1 gene rearrangement at 22q12, confirming the diagnosis of desmoplastic small round cell tumor.
UNASSIGNED: Being different from the predilection of
DSRCT for young men, the patient in our case is a 65-year-old man with a huge mass involving the transverse colon and the bladder.