垂体腺瘤(PA)可能会压缩光学装置,导致视力受损。一些患者可以在手术后迅速改善视力。在手术后的早期,然而,外皮层和高级认知皮层的神经功能变化还有待探索。
我们的研究集中在PA患者视力恢复后的外静息状态网络的变化。
我们招募了14例PA患者,这些患者在手术后视力得到改善。6个种子的功能连接(FC)[听觉皮层(A1),布罗卡区,默认模式网络(DMN)的后扣带皮质(PCC),评估了右侧尾前扣带回皮质的显著性网络(SN)和左侧背外侧前额叶皮质的执行控制网络(ECN)]。进行配对t检验以确定两组患者之间的差异。
与术前同行相比,视力改善的PA患者表现出FC降低,左脑岛小叶右侧A1,右侧颞中回和左侧中央后回,右侧中央旁小叶FC增加;左侧颞中回的BrocaFC减少,左侧岛叶小叶和右侧丘脑FC增加;右侧和右侧前突的DMNFC减少;右侧Brodmann17区,左侧骨and和右侧后扣带的FC增加;右侧FC减少,右侧ECF减少。右角和右前肌;随着右侧颞中回SN的减少,右侧海马,和右前外侧;右梭状回的FC增加,左舌回和右Brodmann区19。
视力恢复可能会引起与A1和Broca相关的跨模态可塑性和多感觉系统的反应。DMN和SN可以参与视觉皮层内的子区域的自顶向下控制。前突可能参与了DMN,同时ECN和SN。
Pituitary adenoma (PA) may compress the optic apparatus, resulting in impaired vision. Some patients can experience improved vision rapidly after surgery. During the early period after surgery, however, the change in neurofunction in the extravisual cortex and higher cognitive cortex has yet to be explored.
Our study focused on the changes in the extravisual resting-state networks in patients with PA after vision restoration.
We recruited 14 patients with PA who experienced visual improvement after surgery. The functional connectivity (FC) of 6 seeds [auditory cortex (A1), Broca\'s area, posterior cingulate cortex (PCC) for the default mode network (DMN), right caudal anterior cingulate cortex for the salience network (SN) and left dorsolateral prefrontal cortex for the executive control network (ECN)] were evaluated. A paired t test was conducted to identify the differences between two groups of patients.
Compared with their preoperative counterparts, patients with PA with improved vision exhibited decreased FC with the right A1 in the left insula lobule, right middle temporal gyrus and left postcentral gyrus and increased FC in the right paracentral lobule; decreased FC with the Broca in the left middle temporal gyrus and increased FC in the left insula lobule and right thalamus; decreased FC with the DMN in the right declive and right precuneus; increased FC in right Brodmann area 17, the left cuneus and the right posterior cingulate; decreased FC with the ECN in the right posterior cingulate, right angular and right precuneus; decreased FC with the SN in the right middle temporal gyrus, right hippocampus, and right precuneus; and increased FC in the right fusiform gyrus, the left lingual gyrus and right Brodmann area 19.
Vision restoration may cause a response of cross-modal plasticity and multisensory systems related to A1 and the Broca. The DMN and SN may be involved in top-down control of the subareas within the visual cortex. The precuneus may be involved in the DMN, ECN and SN simultaneously.