背景:胃癌(GC)通常诊断为晚期,因此患者预后不良。这意味着这种癌症的早期检测将改善患者的预后和生存率。本系统综述探讨了循环蛋白和代谢物生物标志物与GC发展的关系。
方法:在Medline上进行了文献检索,直到2021年11月,Embase,科克伦图书馆,和WebofScience数据库。如果他们评估血液中的循环蛋白质和代谢物,尿液,或唾液,并确定它们与GC风险的关系。使用纽卡斯尔-渥太华量表进行队列研究,确定已确定研究的质量。进行随机和固定效应荟萃分析以计算合并比值比。
结果:共纳入53项研究。高水平的抗幽门螺杆菌IgG水平,胃蛋白酶原I(PGI)<30µg/L和血清胃蛋白酶原I/胃蛋白酶原II(PGI/II)比值<3与发生GC的风险呈正相关(合并比值比(OR):2.70;95%CI:1.44-5.04,5.96,95%CI:2.65-13.42和4.43;95%CI:3.04-6.47).此外,发现铁蛋白之间存在反比关系,铁和转铁蛋白水平和发生GC的风险(OR:0.62;95%CI:0.38-1,0.97;95%CI:0.94-1和0.85;95%CI:0.76-0.94)。然而,葡萄糖水平之间没有关联,胆固醇,维生素C,维生素B12,维生素A,α-胡萝卜素,β-胡萝卜素,α-生育酚,γ-生育酚,和GC风险。
结论:汇总分析表明,高水平的抗幽门螺杆菌IgG,PGI<30µg/L,血清PGI/II比值<3,铁蛋白水平低,铁和转铁蛋白与GC风险相关。
Gastric cancer (GC) is often diagnosed at an advanced stage and thus patients have a poor prognosis. This implies that early detection of this cancer will improve patient prognosis and survival. This systematic review explored the association of circulating protein and metabolite biomarkers with GC development.
A literature search was conducted until November 2021 on Medline, Embase, Cochrane library, and Web of Science databases. Studies were included if they assessed circulating proteins and metabolites in blood, urine, or saliva and determined their association with GC risk. Quality of identified studies was determined using the Newcastle-Ottawa scale for cohort studies. Random and fixed effects meta-analyses were performed to calculate pooled odds ratio.
A total of 53 studies were included. High levels of anti-Helicobacter pylORi IgG levels, pepsinogen I (PGI) <30 µg/L and serum pepsinogen I/ pepsinogen II (PGI/II) ratio<3 were positively associated with risk of developing GC (pooled odds ratio (OR): 2.70; 95% CI: 1.44-5.04, 5.96, 95% CI: 2.65-13.42 and 4.43; 95% CI: 3.04-6.47). In addition, an inverse relationship was found between ferritin, iron and transferrin levels and risk of developing GC (OR: 0.62; 95% CI: 0.38-1,0.97; 95% CI: 0.94-1 and 0.85; 95% CI: 0.76-0.94). However, there was no association between levels of glucose, cholesterol, vitamin C, vitamin B12, vitamin A, α-Carotene, β-Carotene, α-Tocopherol, γ-Tocopherol, and GC risk.
The pooled analysis demonstrated that high levels of anti-Helicobacter pylORi IgG, PGI<30µg/L and serum PGI/II ratio <3 and low levels of ferritin, iron and transferrin were associated with risk of GC.