本研究旨在探讨染色体多态性(CPs)是否对体外受精/卵胞浆内单精子注射-胚胎移植(IVF/ICSI-ET)/冻融胚胎移植(FET)的生殖结局产生负面影响?我们进行了一项由21,867个辅助生殖技术治疗周期组成的回顾性研究。其中,新鲜胚胎移植周期占10,400,其余为FET周期。根据CP的核型,前者被分组为:第1组(男性携带者,n=425),第2组(女性携带者,n=262),和第3组(没有CP的夫妇,n=9713)。因此,FET周期分为3组:第4组(男性携带者,n=298),第5组(女性携带者,n=311),和第6组(没有CP的夫妇,n=10858)。胚胎着床率(IR),临床妊娠率(CPR),活产率(LBR),比较各组早期流产率(EMR)。在IVF/ICSI后的新鲜胚胎移植周期中,不孕症持续时间没有显着差异,BMI,基础FSH,不。卵母细胞,不。2PN,触发日子宫内膜厚度,血清E2,P,和LH水平在触发日(P>0.05)。女性年龄,不。2PN胚胎卵裂,高质量的胚胎,和没有。胚胎移植组之间差异有统计学意义(P<0.05)。IR为38.8%,36.2%,第1、2和3组分别为34.0%。心肺复苏率为55.1%,52.3%,49.7%,分别。LBR为36.9%,37.4%,和36.4%,分别。两组之间的CPR和LBR没有显着差异。与第1和第2组相比,第3组的IR较低,EMR较高。二元logistic回归分析表明,女性年龄,不。移植的胚胎,EMT,LH,触发日的P和P是与CPR相关的独立因素。此外,不。移植的胚胎,触发日EMT与LBR相关,而CPs与IVF/ICSI-ET后的CPR和LBR无关。在FET循环中,不孕持续时间相似(P>0.05),但是女性的年龄,BMI,不。胚胎移植组之间差异有统计学意义(P>0.05)。IR为24.3%,第4、5和6组接受率为23.6%和22.3%。心肺复苏率为31.8%,30.9%,和30.0%,LBR为23.8%,26.3%,和23.8%,而EMR为12.6%,13.1%,14.4%,分别。IR,CPR,EMR,LBR和LBR组间差异无统计学意义(P>0.05)。二元logistic回归分析表明,女性年龄,不孕持续时间,和没有。胚胎移植是FET后影响CPR和LBR的独立因素。FET后的CPs与CPR和LBR无关。结果表明,单亲携带CPs对IVF/ICSI-ET/FET后的生殖结局没有影响。然而,尚不清楚携带CPs的父母双方是否会影响妊娠结局.
The present study aimed to explore whether chromosomal polymorphisms (CPs) have negative effects on reproductive outcomes of in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET)/frozen-thawing embryo transfer (FET)? We conducted a retrospective study consisting of 21,867 assisted reproductive technology treatment cycles, among which, fresh embryo transfer cycles accounted for 10,400, and the rest were FET cycles. According to karyotype of CPs, the former was grouped as: group 1 (male carrier, n = 425), group 2 (female carrier, n = 262), and group 3 (couple without CPs, n = 9713). Accordingly, FET cycles were divided into 3 groups: group 4 (male carrier, n = 298), group 5 (female carrier, n = 311), and group 6 (couple without CPs, n = 10,858). The embryo implantation rate (IR), clinical pregnancy rate (CPR), live birth rate (LBR), and early miscarriage rate (EMR) were compared among the groups. In fresh embryo transfer cycles after IVF/ICSI, there were no significant differences in the infertility duration, BMI, basal FSH, no. of oocyte, no. of 2PN, endometrial thickness on trigger day, serum E2, P, and LH level on trigger day (P > 0.05). The female age, no. of 2PN embryo cleavage, top-quality embryo, and no. of embryo transferred were significantly different among groups (P < 0.05). The IR was 38.8%, 36.2%, and 34.0% in groups 1, 2, and 3, respectively. The CPR was 55.1%, 52.3%, and 49.7%, respectively. The LBR was 36.9%, 37.4%, and 36.4%, respectively. The CPR and LBR showed no significant differences among groups. The IR was lower and the EMR was higher in group 3 than those of groups 1 and 2. Binary logistic regression analysis indicated that female age, no. of embryo transferred, EMT, LH, and P on the trigger day were independently factors associated with CPR. Besides, no. of embryo transferred, and EMT on trigger day were associated with LBR, while the CPs was not related with CPR and LBR after IVF/ICSI-ET. In FET cycles, the infertility duration was similar (P > 0.05), but the female age, BMI, no. of embryo transferred were significantly different among groups (P > 0.05). The IR was 24.3%, 23.6% and 22.3% in group 4, 5, and 6, receptivity. The CPR was 31.8%, 30.9%, and 30.0%, the LBR was 23.8%,26.3%, and 23.8%, while the EMR was 12.6%, 13.1%, 14.4%, respectively. The IR, CPR, EMR, and LBR showed no significant differences among groups (P > 0.05). Binary logistic regression analysis indicated that female age, infertility duration, and no. of embryo transferred were independently factors affecting CPR and LBR after FET. The CPs were not associated with CPR and LBR after FET. The results suggested that uniparental carrying of CPs have no effects on the reproductive outcomes after IVF/ICSI-ET/FET. However, it is not clear whether both parents carrying CPs would affect pregnancy outcome.