■寻常痤疮(AV)是一种常见的皮肤病。火针是一种用红热针快速刺穿局部皮肤病变的方法,用于AV。这项工作旨在评估火针结合化学果皮治疗AV的有效性和安全性。
■八个数据库,包括PubMed,EMBASE,科克伦图书馆,WebofScience,中国全民知识互联网,万方,Sinomed,和VIP数据库被搜索到纳入随机对照试验(RCTs),比较火针疗法联合化学换肤和单独化学换肤.偏倚的风险由Cochrane协作的工具进行评估。通过RevMan5.3和Stata14.0完成统计学分析。
■共纳入18项研究,包括1213例患者。与单独的化学果皮相比,火针辅助化学剥皮治疗提高总有效率(RR=1.37,95%CI[1.26,1.48],p<0.00001)和皮肤损伤(MD=-2.11,95%CI[-2.74,-1.47],p<0.00001),并降低复发率(RR=0.50,95%CI[0.33,0.76],p=0.0009)。火针的应用很少有不良反应,所有这些都是良好的耐受性和短暂的。
■火针辅助化学剥离疗法对AV有效且安全。然而,更大规模,精心设计的临床研究有必要提供循证医学支持.
UNASSIGNED: Acne vulgaris (AV) is a common skin disease. Fire needle is a method of quickly piercing the local skin lesions with red-hot needles for AV. This work aimed to evaluate the efficacy and safety of fire needle combined with chemical peels for AV.
UNASSIGNED: Eight databases including PubMed, EMBASE, Cochrane Library, Web of Science,
China National Knowledge Internet, Wanfang, Sinomed, and VIP databases were searched to enrolled randomized controlled trials (RCTs) comparing fire needle therapy combined with chemical peels with chemical peels alone. The risk of bias was evaluated by the Cochrane Collaboration\'s tool. Statistical analysis was completed by RevMan 5.3 and Stata 14.0.
UNASSIGNED: Altogether 18 studies including 1213 patients were enrolled. Compared with chemical peels alone, fire needle adjuvant chemical peels therapy improved the total effective rate (RR = 1.37,95% CI [1.26,1.48], p < 0.00001) and skin lesions (MD = -2.11, 95% CI [-2.74, -1.47], p < 0.00001), and reduced the recurrence rate (RR = 0.50,95% CI [0.33,0.76], p = 0.0009).The application of fire needle was associated with few adverse reactions, all of which were well tolerated and transient.
UNASSIGNED: Fire needle adjuvant chemical peels therapy is effective and safe for AV. Nevertheless, more large-scale, well-designed clinical studies are warranted to provide evidence-based medical support.