目的:动态全身成像可以提供新的视角来研究中枢和外周区域之间的潜在关系。采用uEXPLORER动态[11C]CFTPET/CT成像与逐体素简化参考组织模型(SRTM)动力学建模和半定量测量,我们探讨了黑质纹状体和消化区域之间的相关模式在健康参与者作为对照(HC)和帕金森病(PD)患者之间的差异.
方法:11名参与者(6个HC和5个PD)在全身PET/CT扫描仪上进行了75分钟的动态[11C]CFT扫描(uEXPLORER,联合成像医疗)回顾性登记。四个黑质纹状体核的时间活动曲线(尾状核,壳核,苍白球,和黑质)和三个消化器官(胰腺,胃,和十二指肠)。使用以枕叶为参考组织的SRTM和具有空间约束算法的线性回归,生成了相对转运速率常数(R1)和分布体积比(DVR)的全身参数图像。早期(1-3分钟,SUVREP)和晚期(60-75分钟,SUVRLP)阶段计算为R1和DVR的半定量替代品,分别。
结果:在壳核的DVR和SUVRLP中,HC和PD组之间的估计值存在显着差异(DVR:4.82±1.58vs.2.58±0.53;SUVRLP:4.65±1.36vs.2.84±0.67;对于HC和PD,分别,均p<0.05)和胃的SUVREP(1.12±0.27vs.HC和PD为2.27±0.65,分别为;p<0.01)。在HC组中,胃和黑质之间的R1和SUVREP值均呈负相关(R1为r=-0.83,p<0.05;SUVREP为r=-0.94,p<0.01)。在DVR和SUVRLP值中,胰腺和壳核之间均呈正相关(对于DVR,r=0.94,p<0.01;对于SUVRLP,r=1.00,p<0.001)。相比之下,在PD组,在上述目标黑质纹状体和消化区域之间没有发现相关性.
结论:从SRTM模型生成的R1和DVR的参数图像,以及SUVREP和SUVRLP,建议量化HC和PD组的动态全身[11C]CFTPET/CT。通过R1和DVR鉴定的HC和PD组之间黑质纹状体和消化区域的相关模式的区别,或SUVR,可能为疾病机制提供新的见解。
OBJECTIVE: Dynamic total-body imaging enables new perspectives to investigate the potential relationship between the central and peripheral regions. Employing uEXPLORER dynamic [11C]CFT PET/CT imaging with voxel-wise simplified reference tissue model (SRTM) kinetic modeling and semi-quantitative measures, we explored how the correlation pattern between nigrostriatal and digestive regions differed between the healthy participants as controls (HC) and patients with Parkinson\'s disease (PD).
METHODS: Eleven participants (six HCs and five PDs) underwent 75-min dynamic [11C]CFT scans on a total-body PET/CT scanner (uEXPLORER, United Imaging Healthcare) were retrospectively enrolled. Time activity curves for four nigrostriatal nuclei (caudate, putamen, pallidum, and substantia nigra) and three digestive organs (pancreas, stomach, and duodenum) were obtained. Total-body parametric images of relative transporter rate constant (R1) and distribution volume ratio (DVR) were generated using the SRTM with occipital lobe as the reference tissue and a linear regression with spatial-constraint algorithm. Standardized uptake value ratio (SUVR) at early (1-3 min, SUVREP) and late (60-75 min, SUVRLP) phases were calculated as the semi-quantitative substitutes for R1 and DVR, respectively.
RESULTS: Significant differences in estimates between the HC and PD groups were identified in DVR and SUVRLP of putamen (DVR: 4.82 ± 1.58 vs. 2.58 ± 0.53; SUVRLP: 4.65 ± 1.36 vs. 2.84 ± 0.67; for HC and PD, respectively, both p < 0.05) and SUVREP of stomach (1.12 ± 0.27 vs. 2.27 ± 0.65 for HC and PD, respectively; p < 0.01). In the HC group, negative correlations were observed between stomach and substantia nigra in both the R1 and SUVREP values (r=-0.83, p < 0.05 for R1; r=-0.94, p < 0.01 for SUVREP). Positive correlations were identified between pancreas and putamen in both DVR and SUVRLP values (r = 0.94, p < 0.01 for DVR; r = 1.00, p < 0.001 for SUVRLP). By contrast, in the PD group, no correlations were found between the aforementioned target nigrostriatal and digestive areas.
CONCLUSIONS: The parametric images of R1 and DVR generated from the SRTM model, along with SUVREP and SUVRLP, were proposed to quantify dynamic total-body [11C]CFT PET/CT in HC and PD groups. The distinction in correlation patterns of nigrostriatal and digestive regions between HC and PD groups identified by R1 and DVR, or SUVRs, may provide new insights into the disease mechanism.