Broad autism phenotype

广泛的自闭症表型
  • 文章类型: Journal Article
    目的:我们的主要目的是使用注意力网络测试(ANT)调查自闭症谱系障碍(ASD)儿童父母的注意力网络功能。次要目标是观察所有参与者的三个注意力网络是否彼此相关。
    方法:我们纳入了28名ASD儿童的父母和28名匹配良好的典型发育儿童的父母。所有参与者都接受了神经心理学评估和ANT测试。三个不同的注意力网络,包括警报,定向,和执行控制,也被测量了。
    结果:与对照组相比,ASD儿童的父母表现出效率较低的警报和执行控制网络(所有p<0.05),但不是定向网络(p=0.74)。警报之间没有发现显著的相关性,定向,和任何一组的执行控制网络。
    结论:我们的研究结果表明,ASD儿童的父母在警觉和执行控制注意功能方面存在缺陷。缺陷是广泛的自闭症表型的迹象。
    OBJECTIVE: We primarily aimed to investigate the attention network function among parents of children with autism spectrum disorder (ASD) using the Attention Network Test (ANT). The secondary objective was to observe whether the three attention networks of all participants were related to each other.
    METHODS: We included 28 parents of children with ASD and 28 well-matched parents of typically developing children. All participants underwent the neuropsychological assessment and ANT test. The three distinct attention networks, including alerting, orienting, and executive control, were also measured.
    RESULTS: Compared with controls, parents of children with ASD showed less-efficient alerting and executive control network (all p<0.05), but not orienting network (p=0.74). No significant correlation was found between the alerting, orienting, and executive control network for either group.
    CONCLUSIONS: Our findings showed that parents of children with ASD had deficits in alerting and executive control attention functions. The deficits are indications of a broad autism phenotype.
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  • 文章类型: Journal Article
    广泛自闭症表型(BAP)是指一组症状或个性特征,这些症状或个性特征类似但不符合自闭症性障碍(ASD)患者亲属的自闭症诊断标准。广泛自闭症表型问卷(BAPQ)是测量BAP的新的和广泛使用的评估工具之一。它已被翻译成8种不同的语言,并且对某些版本的心理测量特性进行了研究,但不包括中文版(BAPQ-C)。本研究旨在分析BAPQ-C的信度和效度,并探讨其在中国人群中的适用性。该研究包括1,618个家庭,包括890名ASD儿童和728名典型发育(TD)儿童。我们的结果没有找到一个拟合良好的三因素(Aloof,刚性的,语用语言)结构,与以前的研究一致。但是我们形成了一个模型,只包括了Alof和语用语言维度。去除刚性尺寸后的参数明显更好。本研究表明,简短版本的Aloof和语用语言子量表具有良好的信度和效度,可用于研究中国人群的BAP。然而,仍需要更多的研究来改善BAPQ-C的心理测量特性。
    Broad Autism Phenotype (BAP) refers to a set of symptoms or personality traits which similar but not meet the diagnostic criteria for autism in relatives of individuals with Autism Spetrum Disorders (ASD).The Broad Autism Phenotype Questionnaire (BAPQ) is one of the new and widely used assessment tools to measure BAP.It has been translated into 8 different languages and some versions were investigated the psychometric properties but not including Chinese version (BAPQ-C).This study aimed to analyze the reliability and validity of the BAPQ-C and explore its applicability in the Chinese population. 1,618 families were included in the study consisting of 890 ASD children and 728 typically developed(TD)children. Our results did not find a well-fitting three-factor(Aloof,Rigid,Pragmatic language) structure which is consistent with previous studies.But we formed a model that only included Aloof and Pragmatic language dimensions.The parameter after removing the rigid dimension was significantly better.This study indicated that the short version of Aloof and Pragmatic language sub-scales has good reliability and validity and can be used to study BAP in the Chinese population. Nevertheless, more studies are still needed to improve the psychometric properties of the BAPQ-C.
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