■感觉神经性听力损失(SNHL)可由多种先天性和获得性因素引起。及早发现是培养语言的关键,语言,和SNHL儿童的认知发展。在我们的研究中,我们利用合成磁共振成像(SyMRI)评估SNHL患儿脑内灰质和白质的改变.
■该研究涵盖了被诊断为SNHL的儿童和听力正常的对照组儿童{1.5个月大(n=52)和3个月大(n=78)}。参与者根据他们的听觉脑干反应(ABR)阈值进行分类,划分为正常的,温和,中度,和严重的亚组。包括临床参数并评估与SNHL的相关性。使用SyMRI扫描对大脑形态进行定量分析,产生大脑分割和弛豫时间的数据。通过单变量和多变量分析,确定了预测SNHL的独立因素。使用受试者工作特征(ROC)曲线评估预测模型的有效性,通过使用列线图来促进可视化。重要的是要注意,由于我们研究的限制,我们的样本量相对较小。
■新生儿高胆红素血症(NH)和内耳畸形(IEM)患儿在1.5和3个月组均与SNHL发病相关。在3个月组,中度和重度亚组在下丘(IC)表现出升高的定量T1值,外侧板面(LL),与正常组相比,小脑中梗(MCP)。此外,WMV,WMF,MYF,和MYV相对于正常组显著降低。此外,患有IEM的SNHL儿童在IC中具有较高的T1值,以及LL和降低的WMV,WMF,在3个月组中,与无IEM的SNHL儿童相比,MYV和MYF值。LL-T1和WMF是SNHL的独立危险因素。因此,设计了基于LL-T1和WMF的预测模型。训练集的ROC,验证集和外部集分别为0.865,0.806和0.736.
■T1定量值和脑容量分割的整合为跟踪受SNHL影响的儿童的脑发育和评估病情的严重程度提供了一个有价值的工具。
UNASSIGNED: Sensorineural hearing loss (SNHL) can arise from a diverse range of congenital and acquired factors. Detecting it early is pivotal for nurturing speech, language, and cognitive development in children with SNHL. In our study, we utilized synthetic magnetic resonance imaging (SyMRI) to assess alterations in both gray and white matter within the brains of children affected by SNHL.
UNASSIGNED: The study encompassed both children diagnosed with SNHL and a control group of children with normal hearing {1.5-month-olds (n = 52) and 3-month-olds (n = 78)}. Participants were categorized based on their auditory brainstem response (ABR) threshold, delineated into normal, mild, moderate, and severe subgroups.Clinical parameters were included and assessed the correlation with SNHL. Quantitative analysis of brain morphology was conducted using SyMRI scans, yielding data on brain segmentation and relaxation time.Through both univariate and multivariate analyses, independent factors predictive of SNHL were identified. The efficacy of the prediction model was evaluated using receiver operating characteristic (ROC) curves, with visualization facilitated through the utilization of a nomogram. It\'s important to note that due to the constraints of our research, we worked with a relatively small sample size.
UNASSIGNED: Neonatal hyperbilirubinemia (NH) and children with inner ear malformation (IEM) were associated with the onset of SNHL both at 1.5 and 3-month groups. At 3-month group, the moderate and severe subgroups exhibited elevated quantitative T1 values in the inferior colliculus (IC), lateral lemniscus (LL), and middle cerebellar peduncle (MCP) compared to the normal group. Additionally, WMV, WMF, MYF, and MYV were significantly reduced relative to the normal group. Additionally, SNHL-children with IEM had high T1 values in IC, and LL and reduced WMV, WMF, MYV and MYF values as compared with SNHL-children without IEM at 3-month group. LL-T1 and WMF were independent risk factors associated with SNHL. Consequently, a prediction model was devised based on LL-T1 and WMF. ROC for training set, validation set and external set were 0.865, 0.806, and 0.736, respectively.
UNASSIGNED: The integration of T1 quantitative values and brain volume segmentation offers a valuable tool for tracking brain development in children affected by SNHL and assessing the progression of the condition\'s severity.