■手术对晚期前列腺癌(PC)的影响尚不清楚,并且缺乏术后生存的预测模型。
■我们调查了国家癌症研究所的监测,流行病学,和最终结果(SEER)数据库,收集晚期PC患者的临床特征。根据临床经验,年龄,种族,grade,病理学,T,N,M,舞台,尺寸,区域节点为正,检查区域节点,手术,放射治疗,化疗,恶性肿瘤病史,临床Gleason评分(由穿刺活检或前列腺标本经尿道电切术组成),病理Gleason评分(由前列腺切除术标本组成)和前列腺特异性抗原(PSA)是潜在的预测变量.所有样本都分为火车队列(占总数的70%,用于模型训练)和测试队列(占总数的30%,用于模型验证)通过随机抽样。然后,我们开发神经网络来预测高级PC患者的总体情况。接收器工作特性曲线下面积(AUC)用于评估模型的性能。
■6380名患者,诊断为晚期(III-IV期)前列腺癌并接受手术,已被包括在内。该模型使用所有收集的临床特征作为预测因子,并基于神经网络算法,得分为0.7058AUC(95%CI,0.7021-0.7068)在列车队列中和0.6925AUC(95%CIs,0.6906-0.6956)在测试队列中。然后我们将其打包到Windows64位软件中。
■晚期前列腺癌患者可以从手术中获益。为了预测它们的总体生存率,我们首先建立一个基于临床特征的预后模型.该模型具有较高的准确性,可为临床决策提供参考。
UNASSIGNED: The effect of surgery on advanced prostate cancer (PC) is unclear and predictive model for postoperative survival is lacking yet.
UNASSIGNED: We investigate the National Cancer Institute\'s Surveillance, Epidemiology, and End Results (SEER) database, to collect clinical features of advanced PC patients. According to clinical experience, age, race, grade, pathology, T, N, M, stage, size, regional nodes positive, regional nodes examined, surgery, radiotherapy, chemotherapy, history of malignancy, clinical Gleason score (composed of needle core biopsy or transurethral resection of the prostate specimens), pathological Gleason score (composed of prostatectomy specimens) and prostate-specific antigen (PSA) are the potential predictive variables. All samples are divided into train cohort (70% of total, for model training) and test cohort (30% of total, for model validation) by random sampling. We then develop neural network to predict advanced PC patients\' overall. Area under receiver operating characteristic curve (AUC) is used to evaluate model\'s performance.
UNASSIGNED: 6380 patients, diagnosed with advanced (stage III-IV) prostate cancer and receiving surgery, have been included. The model using all collected clinical features as predictors and based on neural network algorithm performs best, which scores 0.7058 AUC (95% CIs, 0.7021-0.7068) in train cohort and 0.6925 AUC (95% CIs, 0.6906-0.6956) in test cohort. We then package it into a Windows 64-bit software.
UNASSIGNED: Patients with advanced prostate cancer may benefit from surgery. In order to forecast their overall survival, we first build a clinical features-based prognostic model. This model is accuracy and may offer some reference on clinical decision making.