目的：我们评估克罗恩病（CD）患者的焦虑和抑郁水平，以确定健康相关生活质量（HRQOL）的预测因素。
方法：在本病例对照研究中，我们招募了50名成人CD患者和50名匹配的患者，健康的控制。所有参与者都完成了自我管理的问卷，包括焦虑自评量表（SAS），抑郁自评量表(SDS),简短表格36健康调查(SF-36)，和简短的炎症性肠病问卷(IBDQ，仅限患者)。我们分析了HRQOL与影响因素之间的关系。
结果：SAS的平均总分，SDS,和SF-36在患者和对照组之间有显著差异。CD活动期患者的IBDQ评分明显低于缓解期患者。与健康对照组相比，CD患者的SF-36评分显着降低。活动性CD患者的SF-36评分明显低于缓解期患者，无并发症患者的SF-36评分明显高于有并发症患者。营养状况良好的患者的SF-36得分也明显高于营养不良的CD患者的得分。
结论：抑郁症，焦虑,疾病活动,并发症,营养状况是CD患者HRQOL下降的预测因素。
OBJECTIVE: We assessed levels of anxiety and depression in patients with Crohn disease (CD) to identify predictors of health-related quality of life (HRQOL).
METHODS: In this case-control study, we enrolled 50 adult patients with CD and 50 matched, healthy controls. All participants completed self-administered questionnaires including the Self-rating Anxiety Scale (SAS), Self-rating Depression Scale (SDS), Short Form-36 Health Survey (SF-36), and Short Inflammatory Bowel Disease Questionnaire (IBDQ, patients only). We analyzed the relationship between HRQOL and influencing factors.
RESULTS: Mean total scores on the SAS, SDS, and SF-36 were significantly different between patients and controls. IBDQ scores among patients in the active phase of CD were significantly lower than those in remission phase. SF-36 scores were significantly lower in patients with CD compared with healthy controls. SF-36 scores among patients with active CD were significantly lower than scores among those in remission, and SF-36 scores in patients without complications were significantly higher than in those with complications. SF-36 scores in patients with good nutritional status were also significantly higher than scores in malnourished patients with CD.
CONCLUSIONS: Depression, anxiety, disease activity, complications, and nutritional status were predictive factors of decreased HRQOL in patients with CD.
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