■抗菌肽(AMPs)可以作用于细菌细胞膜,从而在耐药细菌类型中发挥抗菌作用。因此,AMPs在耐药菌的治疗中受到越来越多的关注。
■采用文献计量学方法梳理了AMPs治疗耐药菌研究的发展和趋势,并绘制了学者的知识结构图。
■自2010年以来,该领域的出版物和引用激增,表明全球对用于治疗耐药细菌的AMP领域的兴趣日益浓厚。作为这一领域的主要国家,中美两国进行了非常深入的交流与合作,这给这个领域注入了源源不断的动力。新老学者都付出了努力,相关领域发展迅速,特别是在新型AMP的合成和改进中。近年来,抗菌肽治疗耐药菌的研究方向逐渐集中在实际应用上,优化给药方式,优化合成模式,筛选新的AMP和其他领域,表明AMPs治疗耐药菌的相关研究成果已进入实际临床阶段,具有较高的现实意义。
■研究历史,全球研究状况,未来的研究热点,并对AMPs在耐药菌治疗中的研究趋势进行了深入探讨,为相关领域内外的研究者提供研究参考和启示。
UNASSIGNED: Antimicrobial peptides (AMPs) can act on the bacterial cell membrane to play an antibacterial role in types of drug-resistant bacteria. Therefore, AMPs have attracted more and more attention in the treatment of drug-resistant bacteria.
UNASSIGNED: Bibliometric analysis was employed to sort out the development and trends in the research of AMPs in the treatment of drug-resistant bacteria and map the knowledge structure for scholars.
UNASSIGNED: Since 2010, the publications and citations in this field have exploded, indicating a growing global interest in the field of AMPs for the treatment of drug-resistant bacteria. And as major countries in this field,
China and the USA had conducted very in-depth exchanges and cooperation, which had injected a steady stream of impetus into this field. Both old and new scholars have made efforts, and related fields have developed rapidly, especially in the synthesis and improvement of novel AMPs. In recent years, research directions in the field of AMPs for the treatment of drug-resistant bacteria gradually focused on the practical application, optimization of drug delivery mode, optimization of synthesis mode, screening of new AMPs and other fields, indicating that the relevant research results of AMPs for the treatment of drug-resistant bacteria had entered the actual clinical stage, with higher practical significance.
UNASSIGNED: The research history, global research status, future research hotspots, and trends of the research of AMPs in the treatment of drug-resistant bacteria were discussed in depth in this study, which can provide research references and inspiration for researchers inside and outside the related field.