高迁移率族蛋白盒1(HMGB1)是存在于所有细胞类型中的高度保守的高迁移率族蛋白的成员。HMGB1在细胞内外发挥着多种作用,取决于其亚细胞定位,context,和翻译后修饰。HMGB1还与各种疾病的进展有关。特别是,HMGB1在CKD进展和预后中发挥重要作用。HMGB1通过激活下游信号参与CKD进展中的多个关键事件,包括肾脏炎症,持续性纤维化的发作,肾脏老化,AKI到CKD的过渡,和重要的心血管并发症。更重要的是,HMGB1在肾脏疾病的慢性病理生理学中起着独特的作用。与急性病变不同。这篇综述描述了HMGB1在肾脏稳态中的调节作用,并总结了HMGB1如何影响CKD的进展和预后。最后,总结了靶向抑制HMGB1改善CKD的一些有前景的治疗策略.尽管HMGB1作为治疗靶点在CKD中的应用面临着一些挑战。对HMGB1的细胞内和细胞外调节机制的更深入了解是CKD发生和进展的基础,可能使HMGB1成为CKD有吸引力的治疗靶点.
High-mobility group protein box 1 (HMGB1) is a member of a highly conserved high-mobility group protein present in all cell types. HMGB1 plays multiple roles both inside and outside the cell, depending on its subcellular localization, context, and post-translational modifications. HMGB1 is also associated with the progression of various diseases. Particularly, HMGB1 plays a critical role in CKD progression and prognosis. HMGB1 participates in multiple key events in CKD progression by activating downstream signals, including renal inflammation, the onset of persistent fibrosis, renal aging, AKI-to-CKD transition, and important cardiovascular complications. More importantly, HMGB1 plays a distinct role in the chronic pathophysiology of kidney disease, which differs from that in acute lesions. This review describes the regulatory role of HMGB1 in renal homeostasis and summarizes how HMGB1 affects CKD progression and prognosis. Finally, some promising therapeutic strategies for the targeted inhibition of HMGB1 in improving CKD are summarized. Although the application of HMGB1 as a therapeutic target in CKD faces some challenges, a more in-depth understanding of the intracellular and extracellular regulatory mechanisms of HMGB1 that underly the occurrence and progression of CKD might render HMGB1 an attractive therapeutic target for CKD.