关于维生素B12参与冠心病(CHD)的证据仍然存在。在考虑CHD相关因素时,先前的研究没有将维生素B12,维生素B6以及维生素E都包括在内的先例。我们的数据来自国家健康和营养检查调查(NHANES),涵盖2003-2020年期间。该横断面研究包括33,640个样本。我们使用了一个未调整的协变量和三个调整的协变量。维生素E的摄入量百分比,使用多变量逻辑回归分析和亚组逻辑回归将B6和B12分为连续变量和分类变量。为了估计这些趋势,我们应用了维生素E的百分比类别,B6和B12作为连续变量。我们记录了维生素E,B6,B12,年龄,种族,BMI,性别,家庭年收入,教育水平,高血压状态,糖尿病状态,吸烟状况,以及所含样品的饮酒状况。多因素回归分析显示,维生素E和B6与冠心病呈负相关,具有一定的保护作用。维生素B12与冠心病的相关性不大。根据维生素E和维生素B6百分比的四分位数,在第三个四分位数(Q3)中观察到最强的保护作用。亚组分析显示维生素B6和维生素E对女性冠心病的影响更为明显,参与者的BMI在25-30范围内,和吸烟的参与者。我们确定了维生素E和维生素B6对冠心病的可能保护作用,尤其是女性,肥胖,和吸烟人群,而收入和教育也被视为可以考虑的影响因素。
Conflicting evidence still exists regarding Vitamin B12\'s involvement in coronary heart disease (CHD). There is no precedent for previous studies to include both Vitamin B12, Vitamin B6, as well as Vitamin E in the consideration of CHD associating factors. Our data derived from the National Health and Nutrition Examination Survey (NHANES), which covers the period 2003-2020. 33,640 samples were included in this cross-sectional study. We used an unadjusted covariates and three adjusted covariates. The intake percentage of Vitamins E, B6, and B12 was categorized into continuous and categorical variables using multivariate logistic regression analysis and subgroup logistic regression. To estimate these trends, we applied the percentage categories of Vitamin E, B6, and B12 intake as continuous variables. We recorded Vitamin E, B6, B12, age, race, BMI, gender, household annual income, education level, hypertension status, diabetes status, smoking status, and drinking status for included samples. Multivariate regression analysis revealed that Vitamin E and B6 were negatively associated with CHD and exerted protective effects, while Vitamin B12 had little correlation with CHD. Based on the quartiles of Vitamin E and Vitamin B6 percentage, the strongest protective effect was observed in the third quartile (Q3). Analyses of subgroups showed the effects of Vitamin B6 and Vitamin E on CHD were more noticeable in women, the participant\'s BMI was in the 25-30 range, and participants who smoked. We identified the possible protective effect of Vitamin E and Vitamin B6 against CHD, especially in female, obese, and smoking populations, whereas income and education were also viewed as influencing factors that could be taken into account.