背景:维生素B缺乏与生育和妊娠的多种结局有关。在巴西,育龄妇女中这些微量营养素缺乏的全国患病率尚不清楚.本研究旨在系统地识别,选择,评估,分析,报告巴西育龄妇女维生素B复合物缺乏的患病率,并确定可能改变结果率的变量。
方法:将根据以下问题进行系统评价:“巴西育龄妇女维生素B缺乏的患病率是多少?”将使用电子数据库从文献检索中识别和选择这些研究,咨询研究人员/专家,以及有关该主题的合格研究和评论的参考列表。主要资格标准包括在巴西进行的观察性横断面和队列研究,并在10-49岁的女性中进行。或怀孕和哺乳期的母亲,并通过实验室测试调查了维生素B复合物的缺乏。两名评审员将独立进行研究的筛选和选择,数据提取,和偏见风险评估。对于数据报告,将使用叙述方法来呈现所纳入研究的特征和个人发现。如果研究足够均匀,将实施随机荟萃分析模型,以汇总整体价值的个体患病率。
结论:本研究旨在确定育龄妇女维生素B复合物缺乏的国家和地区患病率;让政策制定者讨论,plan,并实施公共政策来筛查;并预防和/或治疗这些营养不良状况。这也旨在了解多年来营养缺乏的比率,作为人口社会经济和饮食模式的间接指标。特别是叶酸,这项研究可以比较自2004年以来在巴西实施的小麦和玉米粉强制性强化前后维生素缺乏的患病率,在这个特定的人群中。收集的证据可能凸显了需要进行基于人群的研究来调查这些维生素的缺乏。
背景:PROSPEROCRD42020188474。
Vitamin B deficiencies are involved with several outcomes in fertility and pregnancy. In Brazil, the national prevalence rates of these micronutrient deficiencies in women of reproductive age were not known. This study aims to systematically identify, select, evaluate, analyze, and report the prevalence rates of vitamin B complex deficiencies in women of reproductive age in Brazil and identify variables that may modify the outcome rates.
A systematic
review will be conducted guided by the following question: \"What is the prevalence of vitamin B deficiencies in women of reproductive age in Brazil?\". The studies will be identified and selected from a literature search using electronic databases, consultation with researchers/specialists, and reference lists of eligible studies and reviews on the topic. Major eligibility criteria include observational cross-sectional and cohort studies carried out in Brazil and performed in women 10-49 years old, or pregnant and lactating mothers, and investigated the deficiency of vitamin B complex by laboratory test. Two reviewers independently will perform the screening and selection of the studies, data extraction, and risk of bias assessment. For the data report, a narrative approach will be used to present the characteristics of the included studies and individual findings. A random meta-analysis model will be implemented to summarize the individual prevalence rates in a global value if the studies are sufficiently homogeneous.
This study aims to identify the national and regional prevalence rates of vitamin B complex deficiencies in women of reproductive age; allow the policymakers discuss, plan, and implement public policies to screen; and prevent and/or treat these malnutrition conditions. This also aims to know the rates of nutritional deficiencies over the years, serving as an indirect indicator of the socioeconomic and dietary patterns of the population. Specifically for folate, this study allows to compare the prevalence rates of deficiency of this vitamin before and after the mandatory fortification of wheat and corn flours implemented since 2004 in Brazil, in this specific population. The evidence gathered may highlight the need for population-based studies to investigate the deficiency of these vitamins.
PROSPERO CRD42020188474.