背景:研究表明,短期单眼剥夺会引起感觉眼优势的转变,有利于剥夺眼。然而,短期单眼剥夺如何在空间频率上调节感觉眼优势尚不清楚。为了解决这个问题,我们进行了一项研究,以探讨短期单眼剥夺效应对测试空间频率的依赖性。
方法:10名健康的年轻人(年龄:24.7±1.7岁,四名具有正常视力的男性)参加。我们用半透明贴片剥夺了他们的优势眼2.5小时。眼间对比度(优势眼/非优势眼,即,平衡点[BP]),这表明两只眼睛对双目组合的贡献,是使用双目定向组合任务测量的。我们评估了单眼剥夺是否导致0.5、4或6个周期/度(c/d)的BP变化。以随机方式在三个单独的天进行不同的测试空间频率条件。
结果:我们比较了单眼剥夺前后0.5、4和6c/d的BP。发现BP受剥夺的影响很大,其中感觉眼优势转移到剥夺眼(F1.86,16.76=33.09,P<0.001)。BP在0.5、4和6c/d空间频率下的变化一致(F2,18=0.15,P=0.57)。
结论:由短期剥夺引起的感觉眼优势可塑性不依赖于测试空间频率,这表明它可以为与双眼结局有关的弱视治疗提供实用的解决方案。
BACKGROUND: Studies have shown that short-term monocular deprivation induces a shift in sensory eye dominance in favor of the deprived eye. Yet, how short-term monocular deprivation modulates sensory eye dominance across spatial frequency is not clear. To address this issue, we conducted a study to investigate the dependence of short-term monocular deprivation effect on test spatial frequency.
METHODS: Ten healthy young adults (age: 24.7 ± 1.7 years, four males) with normal vision participated. We deprived their dominant eye with a translucent patch for 2.5 h. The interocular contrast ratio (dominant eye/non-dominant eye, i.e., the balance point [BP]), which indicates the contribution that the two eyes make to binocular combination, was measured using a binocular orientation combination task. We assessed if BPs at 0.5, 4 or 6 cycles/degree (c/d) change as a result of monocular deprivation. Different test spatial frequency conditions were conducted on three separate days in a random fashion.
RESULTS: We compared the BPs at 0.5, 4 and 6 c/d before and after monocular deprivation. The BPs were found to be significantly affected by deprivation, where sensory eye dominance shift to the deprived eye (F1.86, 16.76 = 33.09, P < 0.001). The changes of BP were consistent at 0.5, 4, and 6 c/d spatial frequencies (F2,18 = 0.15, P = 0.57).
CONCLUSIONS: The sensory eye dominance plasticity induced by short-term deprivation is not dependent on test spatial frequency, suggesting it could provide a practical solution for amblyopic therapy that was concerned with the binocular outcome.