vestibular neuritis

前庭神经炎
  • 文章类型: Journal Article
    背景:短期糖皮质激素是治疗前庭神经炎(VN)专家考虑的治疗策略之一。我们进行了一项综述(系统评价的系统评价),以总结使用皮质类固醇治疗VN的证据。
    方法:我们纳入了随机对照试验(RCT)和观察性研究的系统评价,这些研究评估了糖皮质激素与安慰剂或常规治疗对成年急性VN患者的影响。标题,摘要,全文一式两份。使用AMeaSurement工具评估系统评论(AMSTAR-2)工具评估评论的质量。建议的分级,评估,开发和评估(GRADE)评估用于评估证据的确定性。未进行荟萃分析。
    结果:来自149个标题,选择了五项系统评价进行质量评估,两篇综述的方法学质量较高,被纳入。这两项综述包括12项个体研究和660例VN患者。在两项RCT的荟萃分析中,包括总共50名患者,使用皮质类固醇(与安慰剂相比)与更高的完全热量恢复相关(风险比2.81,95%置信区间[CI]1.32~6.00,低确定性).非常不确定这是否转化为临床改善,如患者报告的眩晕或患者报告的头晕残疾等结果的不精确效果估计所示。头晕障碍评分的结果有一个广泛的CI(一项研究,30名患者,皮质类固醇组的20.9分与安慰剂15.8分,平均差异+5.1,95%CI-8.09至+18.29,非常低的确定性)。据报道,接受皮质类固醇治疗的患者的轻微不良反应发生率较高,但是这个证据的确定性很低。
    结论:支持在急诊科使用皮质类固醇治疗VN的证据有限。
    A short course of corticosteroids is among the management strategies considered by specialists for the treatment of vestibular neuritis (VN). We conducted an umbrella review (systematic review of systematic reviews) to summarize the evidence of corticosteroids use for the treatment of VN.
    We included systematic reviews of randomized controlled trials (RCTs) and observational studies that evaluated the effects of corticosteroids compared to placebo or usual care in adult patients with acute VN. Titles, abstracts, and full texts were screened in duplicate. The quality of reviews was assessed with the A MeaSurement Tool to Assess systematic Reviews (AMSTAR-2) tool. The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) assessment was used to rate certainty of evidence. No meta-analysis was performed.
    From 149 titles, five systematic reviews were selected for quality assessment, and two reviews were of higher methodological quality and were included. These two reviews included 12 individual studies and 660 patients with VN. In a meta-analysis of two RCTs including a total of 50 patients, the use of corticosteroids (compared to placebo) was associated with higher complete caloric recovery (risk ratio 2.81, 95% confidence interval [CI] 1.32 to 6.00, low certainty). It is very uncertain whether this translates into clinical improvement as shown by the imprecise effect estimates for outcomes such as patient-reported vertigo or patient-reported dizziness disability. There was a wide CI for the outcome of dizziness handicap score (one study, 30 patients, 20.9 points in corticosteroids group vs. 15.8 points in placebo, mean difference +5.1, 95% CI -8.09 to +18.29, very low certainty). Higher rates of minor adverse effects for those receiving corticosteroids were reported, but the certainty in this evidence was very low.
    There is limited evidence to support the use of corticosteroids for the treatment of VN in the emergency department.
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  • 文章类型: Journal Article
    目的:比较上前庭神经炎(SVN)患者与一般法国人群中心血管危险因素(CVRF)的患病率,并检查急性前庭上缺损血管病因的可能性。
    方法:一项单中心回顾性研究比较了高胆固醇血症的患病率,高血压,糖尿病,吸烟,SVN患者与法国普通人群之间的心血管疾病和心房颤动。纳入标准包括:持续数天的旋转性眩晕,没有听力损伤或神经体征,视频头部脉冲测试(vHIT)上的前半规管和外侧半规管受累。一位高级放射科医生在桥小脑MRI上分析了前庭上神经和内耳结构的增强。
    结果:纳入2016年5月至2020年2月的118例SVN。统计分析涉及106例。SVN人群的高胆固醇血症(RR=0.40)明显少于法国普通人群。其他CVRF无显著差异。在84%的MRI上观察到前庭上神经增强。
    结论:SVN患者的CVRF患病率并不高于一般人群。本研究强调了SVN中前庭上神经的受累多于前庭前动脉的受累。
    OBJECTIVE: To compare the prevalence of cardiovascular risk factors (CVRF) in patients with superior vestibular neuritis (SVN) versus the general French population, and to examine the possibility of vascular etiology in acute superior vestibular deficit.
    METHODS: A single-center retrospective study compared the prevalence of hypercholesterolemia, hypertension, diabetes, smoking, cardiovascular disease and atrial fibrillation between patients with SVN and the French general population. Inclusion criteria comprised: rotatory vertigo lasting several days, without hearing impairment or neurological signs, with anterior and lateral semicircular canal involvement on video-Head-Impulse-Test (vHIT). A senior radiologist analyzed superior vestibular nerve and inner ear structure enhancement on cerebellopontine MRI.
    RESULTS: One hundred and eighteen cases of SVN were included from May 2016 to February 2020. Statistical analyses concerned 106 cases. The SVN population had significantly less hypercholesterolemia (RR=0.40) than the general French population. There was no significant difference concerning other CVRFs. Superior vestibular nerve enhancement was observed on 84% of MRIs.
    CONCLUSIONS: Prevalence of CVRF was not higher in patients with SVN than in the general population. The present study highlighted involvement of the superior vestibular nerve more than of the anterior vestibular artery in SVN.
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  • 文章类型: Journal Article
    The virtual practice has made major advances in the way that we care for patients in the modern era. The culture of virtual practice, consulting, and telemedicine, which had started several years ago, took an accelerated leap as humankind was challenged by the novel coronavirus pandemic (COVID19). The social distancing measures and lockdowns imposed in many countries left medical care providers with limited options in evaluating ambulatory patients, pushing the rapid transition to assessments via virtual platforms. In this novel arena of medical practice, which may form new norms beyond the current pandemic crisis, we found it critical to define guidelines on the recommended practice in neurotology, including remote methods in examining the vestibular and eye movement function. The proposed remote examination methods aim to reliably diagnose acute and subacute diseases of the inner-ear, brainstem, and the cerebellum. A key aim was to triage patients into those requiring urgent emergency room assessment versus non-urgent but expedited outpatient management. Physicians who had expertise in managing patients with vestibular disorders were invited to participate in the taskforce. The focus was on two topics: (1) an adequate eye movement and vestibular examination strategy using virtual platforms and (2) a decision pathway providing guidance about which patient should seek urgent medical care and which patient should have non-urgent but expedited outpatient management.
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