背景:过早卵巢功能不全(POI)是指在40岁之前卵巢中卵母细胞的数量和/或质量急剧下降,是女性不孕的主要原因。POI的患病率逐年增加,并且趋于年轻。关于POI的病因及相关发病机制的研究还很有限。草药可以治疗许多妇科疾病。而草药在不孕症等生殖保健方面是有效的。近年来,已经发现细胞因子(CK)的免疫调节可以预防或干预POI,中药可以通过调节CK来治疗POI,以改善卵巢功能和生育能力。
目的:本文就POI相关CK调控的分子机制进行综述,并报告了草药对POI的治疗效果,包括草药配方,单一草药,中药活性成分和针灸。本综述为POI的临床防治提供理论支持,为中药治疗POI的研究提供了新的思路。
方法:我们收集了来自不同科学数据库的有关通过调节CK对POI的草药治疗作用的相关科学文章,包括PubMed,WebofScience,万方数据库,CNKI及其他出版物资源本评论中使用的搜索词包括,\'过早卵巢功能不全\',\'卵巢早衰(POF)\',\'不孕症\',\'草药\',\'针灸\',\'细胞因子\',\'白细胞介素(IL)\',“肿瘤坏死因子-α(TNF-α)”,\'干扰素-γ(IFN-γ)\',转化生长因子-β(TGF-β)血管内皮生长因子(VEGF)\'免疫\'和\'炎症\'。本文根据现有的实验和临床研究,对中药的治疗效果进行了总结和分析。
结果:结果表明,草药通过CK(包括IL,TNF-α,INF-γ,VEGF,TGF-β等)和相关信号通路,调节生殖激素紊乱,减少卵巢炎症损伤,氧化应激,细胞凋亡和卵泡闭锁,改善卵巢病理损伤和卵巢储备功能。
结论:这篇综述通过调节CK丰富了基于中药的POI治疗理论。应加强中药治疗POI的具体作用机制和临床研究,以促进中药在临床的应用,为POI的治疗提供新的思路和更好的选择。
BACKGROUND: Premature ovarian insufficiency (POI) refers to a dramatic decrease in the number and/or quality of oocytes in the ovaries before the age of 40 years, and is a key cause of female infertility. The prevalence of POI has been increasing annually and tends to be younger. Researches on the etiology of POI and related pathogenesis are still very limited. Herbal medicine can treat many gynecological diseases. And herbal medicine is effective in reproductive health care such as infertility. In recent years, it has been found that immune modulation by cytokines (CK) can prevent or intervene in POI, and herbal medicine can treat POI by regulating CK to improve ovarian function and fertility.
OBJECTIVE: This
review presents an overview of the molecular mechanisms of regulation of POI related CK, and reports the therapeutic effect of herbal medicine on POI including herbal medicine formulas, single herbal medicine, herbal medicine active components and acupuncture. This
review provides theoretical support for clinical prevention and treatment of POI, and provides new ideas for researches on herbal medicine treatment of POI.
METHODS: We performed a collection of relevant scientific articles from different scientific databases regarding the therapeutic effect of herbal medicine on POI by regulating CK, including PubMed, Web of Science, Wanfang Database, CNKI and other publication resources. The search terms used in this
review include, \'premature ovarian insufficiency\', \'premature ovarian failure (POF)\', \'infertility\', \'herbal medicine\', \'acupuncture\', \'cytokine\', \'interleukin (IL)\', \'tumor necrosis factor-α (TNF-α)\', \'interferon-γ (IFN-γ)\', \'transforming growth factor-β (TGF-β)\', \'vascular endothelial growth factor (VEGF)\', \'immune\' and \'inflammation\'. This
review summarized and analyzed the therapeutic effect of herbal medicine according to the existing experimental and clinical researches.
RESULTS: The results showed that herbal medicine treats POI through CK (including ILs, TNF-α, INF-γ, VEGF, TGF-β and others) and related signaling pathways, which regulates reproductive hormones disorder, reduces ovarian inflammatory damage, oxidative stress, apoptosis and follicular atresia, improves ovarian pathological damage and ovarian reserve function.
CONCLUSIONS: This
review enriches the theory of POI treatments based on herbal medicine by regulating CK. The specific mechanisms of action and clinical researches on the treatment of POI by herbal medicine should be strengthened in order to promote the application of herbal medicine in the clinic and provide new ideas and better choices for the treatment of POI.