背景:带状疱疹(HZ;即带状疱疹)是由水痘带状疱疹病毒的重新激活引起的,导致疼痛的皮肤科皮疹。在全球范围内,HZ病例的增加趋势是显而易见的;然而,缺乏对东南亚国家的全面审查。
方法:我们对2022年5月之前发表的报告HZ流行病学的文章进行了系统的文献综述,临床管理,和六个东南亚国家的卫生经济数据:印度尼西亚,马来西亚,菲律宾,新加坡,泰国,和越南。文献检索在Medline进行,Scopus,Embase,灰色文学用英语或当地语言撰写的文章被考虑列入。
结果:总计,该研究包括72种出版物;22种是案例研究,超过60%来自新加坡和泰国。只有两项研究(来自泰国的数据)报告了HZ的发生率。在皮肤科诊所中,HZ患者的比例为0.68-0.7%,新加坡一个急诊科的0.14%(皮肤科病例的5.3%),以及新加坡另一家医院住院的3%。疼痛是与HZ相关的最常见症状,74.21-100%的患者报告。在10.2-21.2%的患者中报告了HZ并发症,带状疱疹后神经痛和HZ眼的比例分别为6.3-50%和4.98-28.57%,分别。此外,缺乏全面的,最新的HZ经济数据,只有六项针对菲律宾的研究,新加坡,和泰国。
结论:总体而言,在全国范围内,报告东南亚HZ发病率和患病率的数据有限。并发症发生率高,症状,大量的病例报告表明,HZ患者可以利用大量的医疗保健资源,并强调需要在东南亚进行进一步的研究,以评估其社会影响。
BACKGROUND: Herpes zoster (HZ; i.e., shingles) is caused by the reactivation of varicella zoster virus leading to a painful dermatomal rash. An increasing trend in cases of HZ is evident worldwide; however, there is a lack of comprehensive reviews for Southeast Asian countries.
METHODS: We performed a systematic literature
review of articles published until May 2022 that reported HZ epidemiology, clinical management, and health economic data in six Southeast Asian countries: Indonesia, Malaysia, the Philippines, Singapore, Thailand, and Vietnam. Literature searches were conducted in Medline, Scopus, Embase, and gray literature. Articles written in English or local languages were considered for inclusion.
RESULTS: In total, 72 publications were included in the study; 22 were case studies and over 60% originated in Singapore and Thailand. Only two studies (data from Thailand) reported incidence of HZ. The proportion of patients reported with HZ was 0.68-0.7% among dermatology clinics, 0.14% at one emergency department (5.3% of dermatology cases) in Singapore, and 3% of admissions at another hospital in Singapore. Pain was the most common symptom associated with HZ, reported in 74.21-100% of patients. HZ complications were reported in 10.2-21.2% of patients, and the proportions with postherpetic neuralgia and HZ ophthalmicus were 6.3-50% and 4.98-28.57%, respectively. Additionally, there is a lack of comprehensive, up-to-date HZ economic data, with only six studies identified for the Philippines, Singapore, and Thailand.
CONCLUSIONS: Overall, there are limited data reporting incidence and prevalence of HZ in Southeast Asia at a national level. High rates of complications, symptoms, and abundance of case reports suggest substantial healthcare resource utilization for patients with HZ and highlight the need for further research in Southeast Asia assessing the societal impact.