vaginal delivery

阴道分娩
  • 文章类型: Journal Article
    从单尺度模型到多尺度模型的有限元模型已被广泛用于获得对生理输送过程和相关并发症场景的有价值的见解。然而,子宫收缩活跃的胎儿下降模拟对于验证和不确定性量化问题仍然具有挑战性。本研究使用主动子宫收缩进行了胎儿下降模拟。然后,使用理论和体内MRI分娩数据评估模拟结果。此外,还进行了参数不确定性和传播。开发了母体骨盆模型。使用横向各向同性的Mooney-Rivlin材料对主动子宫收缩进行建模。在模拟之间比较了位移轨迹,理论和体内MRI分娩数据。蒙特卡洛(M.C)和多项式混沌展开(PCE)方法用于量化不确定参数及其传播。获得的结果表明,胎儿下降行为与基于MRI的观察以及理论轨迹(Carus曲线)一致。头部向下的垂直位移范围从0到大约47mm。在模拟期间观察到子宫大小减少50%。还鉴定了三个高灵敏度参数(C1、C2、Ca0)。我们的研究表明,使用主动子宫收缩对于模拟阴道分娩至关重要,但整体参数敏感性,参数不确定度,和结果评估应谨慎执行。作为一个视角,所开发的方法可以外推用于患者特异性建模和相关的分娩并发症模拟,以确定风险和潜在的治疗方案.
    Finite element models ranging from single to multiscale models have been widely used to gain valuable insights into the physiological delivery process and associated complication scenarios. However, the fetus descent simulation with the active uterine contraction is still challenging for validation and uncertainty quantification issues. The present study performed a fetus descent simulation using the active uterine contraction. Then, simulation outcomes were evaluated using theoretical and in vivo MRI childbirth data. Moreover, parameter uncertainty and propagation were also performed. A maternal pelvis model was developed. The active uterine contraction was modeled using a transversely isotropic Mooney-Rivlin material. Displacement trajectories were compared between simulation, theoretical and in vivo MRI childbirth data. Monte Carlo (M.C) and Polynomial Chaos Expansion (PCE) methods were applied to quantify uncertain parameters and their propagations. Obtained results showed that fetal descent behavior is consistent with the MRI-based observation as well as the theoretical trajectory (curve of Carus). The head downward vertical displacement ranges from 0 to approximately 47 mm. A reduction of 50% in uterine size was observed during the simulation. Three high-sensitive parameters (C1,C2,Ca0) were also identified. Our study suggested that the use of the active uterine contraction is essential for simulating vaginal delivery but the global parameter sensitivity, parameter uncertainty, and outcome evaluation should be carefully performed. As a perspective, the developed approach could be extrapolated for patient-specific modeling and associated delivery complication simulations to identify risks and potential therapeutic solutions.
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  • 文章类型: Journal Article
    目的:预测阴道分娩的成功是预防母婴不良结局的重要问题。这项研究旨在检查进展角度(AoP)的测量是否可以预测具有低(4>)Bishop评分的晚期未产妇女引产(IoL)后成功的阴道分娩。
    方法:这项前瞻性研究包括胎龄为41周和1-6天(晚期)的连续未产孕妇。测量AoP至少三次,并计算它们的平均值。
    结果:在研究期间,150名女性的数据被纳入最终分析.38名妇女因进展失败(n=30)或NRGHR(n=8)而接受了CS,而其余的112名妇女接受了NVD,四个女人需要抽真空.两组在年龄方面相似,胎龄,BMI,估计胎儿体重,出生体重。接受NVD的女性与接受CS的女性在超声检查AoP方面存在显着差异(113.8±11.9°vs.98.1±10.9°,p=0.0001),使用地诺前列酮的持续时间较短,缩短劳动收缩时间,和较短的劳动时间。在ROC分析中,AoP的截止值为100°,用于预测NVD的成功IoL,灵敏度为96%,特异性为63%。
    结论:AoP可能是预测晚期行IoL的未产妇女阴道分娩成功的有用超声参数;AOP大于100°与阴道分娩率高相关。
    OBJECTIVE: Predicting the success of vaginal delivery is an important issue in preventing adverse maternal and neonatal outcomes. This study sought to examine whether measurement of the angle of progression (AoP) can predict a successful vaginal delivery following induction of labour (IoL) among late term nulliparous women with a low (4>) Bishop score.
    METHODS: This prospective study included consecutive nulliparous pregnant women whose gestational age was 41 weeks and 1-6 days (late-term). The AoP was measured at least three times and their means were calculated.
    RESULTS: During the study period, data of 150 women were included in the final analysis. Thirty-eight women underwent CS due to failure to progress (n=30) or NRGHR (n=8), while the remaining 112 women underwent NVD, with four women requiring vacuum extraction. The two groups were similar with respect to age, gestational age, BMI, estimated foetal weight, and birth weight. Women undergoing NVD differed significantly from those undergoing CS with respect to a greater ultrasonographic AoP (113.8±11.9° vs. 98.1±10.9°, p=0.0001), a shorter duration of dinoprostone use, shorter time to labour contraction, and a shorter duration of labour. In ROC analysis, the cut-off value for AoP was 100° for the prediction of successful IoL for NVD, with a sensitivity of 96 % and a specificity of 63 %.
    CONCLUSIONS: AoP may be a useful sonographic parameter for predicting successful vaginal delivery among nulliparous women at late term undergoing IoL; an AOP wider than 100° is associated with a high rate of vaginal delivery.
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  • 文章类型: Journal Article
    阴道分娩期间,准妈妈的骨盆发生微妙但明显的运动,在所有骨盆关节和身体的解剖平面(矢状,额叶,和横向)。这些运动的目的是通过扩大各个骨盆平面逐渐扩大小骨盆的空间,以便新生儿的头部可以进入骨盆入口,安全地穿过骨盆的狭窄平面,通过骨盆出口.从生物力学的角度来看,这些运动在文献中被描述为骶骨和髂骨的反动和章动。骶骨的反转有助于扩大骨盆入口的平面。骶骨的章动有助于扩大骨盆宽度的平面,高度,和出口。这些生理运动受到身体构成的影响,母亲的肌筋膜和骨骼系统的状态,而且,通过激素分离的连接,在准妈妈的骨盆与传递机制本身的进展。决定各个关节运动范围的主要因素,因此,各个骨盆平面的充分扩张,是分娩期间母亲的位置。为了最大程度地扩大各个骨盆平面和利用母亲骨盆的最大有效能力,需要母亲的主动运动以及对下腰椎区域和髋关节的软组织的被动拉伸。分娩期间的骨盆。这些动作有助于唤起肌肉上的外展力,肌腱,和骨盆中的韧带导致关节的最佳设置,在此期间发生输送运动。骨盆关节的特定运动预先确定了章动或反动是可能的,因此,如果新生儿的头部可以前进到骨盆入口或通过狭窄和宽骨盆平面,和骨盆出口。分娩期间骨盆的这些生物力学原理和运动的知识使产科医生和助产士能够了解孕妇髋关节的运动如何积极影响小骨盆的空间比。以及如何在非进步劳动的情况下支持进一步的进步。
    Subtle but demonstrable movements in the expectant mother\'s pelvis occur during vaginal delivery in all the pelvic joints and anatomical planes of the body (sagittal, frontal, and transverse). The purpose of these movements is to gradually expand the space in the lesser pelvis via widening of the individual pelvic planes so that the newborn\'s head can enter the pelvic inlet, safely pass through the narrow planes of the pelvis, and through the pelvic outlet. From the point of view of biomechanics, these movements are described in literature as counternutation and nutation of the sacrum and iliac bone. The counternutation of the sacrum helps to expand the plane of the pelvic inlet. The nutation of the sacrum assists in expanding the plane of the pelvic width, height, and outlet. These physiological movements are affected by the body constitution, the state of the myofascial and skeletal systems of the mother, and furthermore, by hormonal disjunction of the connections in the expectant mother\'s pelvis together with the progress of the delivery mechanism itself. The main factor that determines the range of movement in the individual joints, and therefore adequate expansion of the individual pelvic planes, is the position of the mother during delivery. Engagement of active movements of the mother together with application of passive stretching of the soft tissues in the lower lumbar area and in the hip joints are both needed for maximum expansion of the individual pelvic planes and utilization of the maximum useful capacity of the mother\'s pelvis during delivery. These movements help invoke the abduction forces on muscles, tendons, and ligaments in the pelvis that lead to the optimum setting of the joints during which delivery movements happen. The specific movements in the pelvic joints predetermine whether nutation or counternutation is possible, and therefore if the newborn\'s head can progress to the pelvic inlet or pass through the narrow and wide pelvic planes, and the pelvic outlet. The knowledge of these biomechanical principles and movements in the pelvis during delivery enables obstetricians and midwives to understand how the movements in the hip joints of the expectant mother can positively impact the spatial ratios in the lesser pelvis, and how to support further progress in the event of non-progressive labour.
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  • 文章类型: Journal Article
    目的:本研究旨在确定分娩方式对产妇产后舒适度和母乳喂养自我效能的影响。
    方法:本研究作为系统综述和荟萃分析进行。搜索于2022年3月至7月在PubMed上进行,国家论文中心,Dergi公园,谷歌学者,WebofScience,和EBSCO搜索引擎,我们纳入了过去10年的研究。采用横断面研究中使用的JoannaBriggs研究所关键评估工具来评估方法学质量,并使用随机效应模型对所有结果进行荟萃分析。研究数据由平均差计算的连续变量组成。
    结果:从收到的3732条记录中,21项涉及5266名参与者的横断面研究被确定为符合条件。Meta分析结果显示剖宫产降低了产后舒适度,尽管没有统计学意义(MD:-0.8795%:-1.98-0.24,Z=1.53,p=0.44),而母乳喂养自我效能的综合结果显示,分娩类型不影响母乳喂养自我效能.
    结论:这篇综述的结果对产后护理人员具有临床意义,因为分娩方式对产后舒适度和母乳喂养自我效能的影响已在先前的研究中得到充分证明.作者建议护理人员计划产妇护理以增加他们的舒适度,根据循证实践,考虑可能影响产后舒适度的因素。
    OBJECTIVE: This study was conducted to determine the effect of the mode of delivery on maternal postpartum comfort level and breastfeeding self-efficacy.
    METHODS: The study was conducted as a systematic review and a meta-analysis. Searching was performed from March to July 2022, on PubMed, National Thesis Center, Dergi Park, Google Scholar, Web of Science, and EBSCO search engines and we included studies from the last 10 years. The Joanna Briggs Institute Critical Appraisal tools used in cross-sectional studies were employed to appraise the methodological quality and performed meta-analyses using a random-effects model for all outcomes. Study data consisted of continuous variables calculated by Mean Difference.
    RESULTS: From 3732 records received, 21 cross-sectional studies involving 5266 participants were determined to be eligible. Meta-analysis results showed that cesarean section reduced postpartum comfort, albeit not statistically significant (MD: -0.87 95%: -1.98-0.24, Z = 1.53, p = 0.44), whereas the combined results of breastfeeding self-efficacy showed that delivery type did not affect breastfeeding self-efficacy.
    CONCLUSIONS: The results of this review have clinical implications for postpartum caregivers, as the effects of mode of delivery on postpartum comfort and breastfeeding self-efficacy have been well documented in previous studies. The authors recommend caregivers plan maternal care to increase their comfort, taking into account the factors that may affect postpartum comfort in the light of evidence-based practices.
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  • 文章类型: Journal Article
    分娩代表重大的生活事件,在女人的生活中带来身体和情感的转变。在与分娩相关的其他心理方面,分娩疼痛,死亡焦虑,产后抑郁症在孕产妇和生殖健康领域引起了广泛关注。这项研究旨在评估催眠分娩训练的有效性如何减轻分娩疼痛,减轻死亡焦虑,增强产后幸福感,减少分娩时间,以及焦虑如何加剧分娩时间。
    数据来自民政医院门诊妇产科的(N=50)中青年产后妇女,古吉兰瓦拉的Waseer妇科医院和基本保健单位JalalBallagan,巴基斯坦,通过使用方便的采样技术。在50名妇女中,将其分为对照组(N=25)和实验组(N=25)。他们在怀孕33周时被招募,直到分娩进行催眠训练。疼痛数字评分量表(NPRS),坦普尔死亡焦虑量表(TDAS),和爱丁堡产后抑郁量表(EPDS)用于收集参与者的反应。
    研究结果表明,催眠术训练是显著减轻分娩疼痛的催化剂,死亡焦虑,和产后抑郁症。此外,分析显示,在试验组的女性中,死亡焦虑会加剧产程小时数,而催眠分娩会减少产程小时数。
    它揭示了催眠分娩训练以增强分娩过程的有效性。研究结果强调了产科医生之间合作的重要性,心理学家,和心理健康专业人员制定综合护理计划,解决分娩的生理和心理方面。
    UNASSIGNED: Childbirth represents a significant life event, bringing about both physical and emotional transformations in a woman\'s life. Among other psychological aspects associated with childbirth, labor pain, death anxiety, and postpartum depression have garnered significant attention in the field of maternal and reproductive health. This study is intended to evaluate how the effectiveness of hypnobirthing training alleviates labor pain, mitigates death anxiety enhances postpartum well-being reduces labor hours, and how anxiety exacerbates the duration of labor.
    UNASSIGNED: Data were collected from (N = 50) young and middle-aged postpartum women in the outpatient obstetrics and gynecology departments of the Civil Hospital, Waseer Gynecology Hospital and Basic Health Unit Jalal Ballagan in Gujranwala, Pakistan, by using the convenience sampling technique. Out of 50, women were divided into a control (N = 25) and an experimental group (N = 25). They were recruited during their 33 weeks of pregnancy until childbirth for hypnobirthing training. Numerical Pain Rating Scale (NPRS), Templer Death Anxiety Scale (TDAS), and Edinburgh Postnatal Depression Scale (EPDS) were used to collect participants\' responses.
    UNASSIGNED: Findings proved hypnobirthing training as a catalyst in significantly reducing labor pain, death anxiety, and postpartum depression. Furthermore, the analysis indicated that death anxiety exacerbates the labor duration hours and hypnobirthing decreases the labor hours in the experimental group of women.
    UNASSIGNED: It sheds light on the effectiveness of hypnobirthing training to enhance the birthing process. Findings underscore the significance of collaboration between obstetricians, psychologists, and mental health professionals to develop integrated care plans that address both physical and psychological aspects of childbirth.
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  • 文章类型: Journal Article
    背景:有一个新的需要,系统地调查希腊剖宫产率增加的原因,并采取干预措施,以大幅降低剖宫产率。为此,将探讨参与的希腊产科医生在管理劳动时遵循循证指南并应对其他教育和行为干预措施的能力,以及障碍和推动者。本文讨论的是希腊产科的阶梯式楔形设计干预试验的方案,并牢记上述目标,名为ENGAGE(希腊的ENhancinGvaginaldelevery)。
    方法:希腊的22个选定的产妇单位将参加一项涉及20,000至25,000个分娩的多中心阶梯式随机前瞻性试验,其中两个人每月进入研究的干预期(逐步随机化)。进入研究的产妇护理单位将根据他们进入研究干预阶段的时间将建议的干预措施应用8-18个月。研究的初始阶段还将持续8至18个月,包括观察和记录常规实践(剖宫产,阴道分娩,以及参与单位的孕产妇和围产期发病率和死亡率)。第二阶段,干预期,将包括诸如HSOG(希腊妇产科学会)劳动管理指南的应用等干预措施,关于正确解释心电图的培训,处理阴道分娩中的紧急情况,虽然指导委员会成员将可以讨论和实施组织和行为的变化,回答问题,澄清相关问题,并在定期访问或视频会议期间向参与的医疗保健专业人员提供实际指导。此外,在研究过程中,结果将提供给参与单位,以便他们监测自己的表现,同时也收到关于他们费率的反馈。该研究的最后2个月阶段将致力于完成随访问卷,其中包含干预期结束后发生的孕产妇和新生儿发病率数据。研究的总持续时间估计为28个月。评估的主要结果将是剖宫产率的变化,次要结果将是孕产妇和新生儿的发病率和死亡率。
    结论:该研究预计将产生有关影响的新信息,优势,可能性,以及持续的临床参与和行为实施的挑战,教育,和组织干预措施在希腊剖宫产手术方案中详细描述。这些结果可能会对提高孕产妇和新生儿护理质量的方法产生新的见解,特别是因为这代表了降低希腊高剖宫产率的共同努力,此外,为他们在其他国家的减少指明了道路。
    背景:NCT04504500(ClinicalTrials.gov)。该试验进行了前瞻性登记。伦理参考号:320/23.6.2020,生物伦理和行为委员会,医学院,雅典国立和卡波迪斯大学,雅典,希腊。
    BACKGROUND: There is an emerging need to systematically investigate the causes for the increased cesarean section rates in Greece and undertake interventions so as to substantially reduce its rates. To this end, the ability of the participating Greek obstetricians to follow evidence-based guidelines and respond to other educational and behavioral interventions while managing labor will be explored, along with barriers and enablers. Herein discussed is the protocol of a stepped-wedge designed intervention trial in Greek maternity units with the aforementioned goals in mind, named ENGAGE (ENhancinG vAGinal dElivery in Greece).
    METHODS: Twenty-two selected maternity units in Greece will participate in a multicenter stepped-wedge randomized prospective trial involving 20,000 to 25,000 births, with two of them entering the intervention period of the study each month (stepped randomization). The maternity care units entering the study will apply the suggested interventions for a period of 8-18 months depending on the time they enter the intervention stage of the study. There will also be an initial phase of the study lasting from 8 to 18 months including observation and recording of the routine practice (cesarean section, vaginal birth, and maternal and perinatal morbidity and mortality) in the participating units. The second phase, the intervention period, will include such interventions as the application of the HSOG (the Hellenic Society of Obstetrics and Gynecology) Guidelines on labor management, training on the correct interpretation of cardiotocography, and dealing with emergencies in vaginal deliveries, while the steering committee members will be available to discuss and implement organizational and behavioral changes, answer questions, clarify relevant issues, and provide practical instructions to the participating healthcare professionals during regular visits or video conferences. Furthermore, during the study, the results will be available for the participating units in order for them to monitor their own performance while also receiving feedback regarding their rates. Τhe final 2-month phase of the study will be devoted to completing follow-up questionnaires with data concerning maternal and neonatal morbidities that occurred after the completion of the intervention period. The total duration of the study is estimated at 28 months. The primary outcome assessed will be the cesarean section rate change and the secondary outcomes will be maternal and neonatal morbidity and mortality.
    CONCLUSIONS: The study is expected to yield new information on the effects, advantages, possibilities, and challenges of consistent clinical engagement and implementation of behavioral, educational, and organizational interventions described in detail in the protocol on cesarean section practice in Greece. The results may lead to new insights into means of improving the quality of maternal and neonatal care, particularly since this represents a shared effort to reduce the high cesarean section rates in Greece and, moreover, points the way to their reduction in other countries.
    BACKGROUND: NCT04504500 (ClinicalTrials.gov). The trial was prospectively registered. Ethics Reference No: 320/23.6.2020, Bioethics and Conduct Committee, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
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  • 文章类型: Journal Article
    目的:当前的研究重点是通过检查产科医生对需要特殊经验的特定挑战性阴道分娩的方法来预测产科的未来趋势,如臀位介绍,大体胎儿,双胎妊娠,和真空使用,与他们的住院医师培训经验相比。
    方法:横断面研究分两个阶段进行。第一阶段是定性的,第二阶段是定量的。“访谈”和“调查”技术作为数据收集工具。总的来说,20名产科医生参加了面试,400名产科医生参加了调查。访谈数据使用Maxqda2020定性数据分析程序进行了分析,并使用SPSS25.0版对调查数据进行分析。
    结果:在过去的20年里,在涉及臀位的情况下,从阴道分娩逐渐转向剖宫产,大体胎儿,双胎妊娠,和真空使用。虽然法医学的担忧是不可否认的,产科医生普遍认为剖宫产分娩比阴道分娩更安全,这显著影响了这一趋势.相对而言,年轻的产科医生通常在没有获得足够的阴道分娩知识和技能的情况下完成住院医师培训.
    结论:年轻的产科医生目前在处理臀位的阴道分娩方面缺乏足够的经验,大体胎儿,双胎妊娠,和真空使用。随着高级产科医生退休,这种经验有可能在未来十年内完全消失。政策制定者在制定未来的医疗保健政策时应该考虑到这一点。
    OBJECTIVE: The current study focused on predicting future trends in obstetrics by examining obstetricians\' approaches to specific challenging vaginal delivery that require special experience, such as breech presentation, macrosomic fetus, twin pregnancy, and vacuum use, compared with their residency training experience.
    METHODS: The cross-sectional study was conducted in two phases. The first phase was qualitative and the second phase was quantitative. The \"interview\" and \"survey\" techniques served as data collection tools. In total, 20 obstetricians participated in the interviews, and 400 obstetricians took part in the survey. Data from the interviews were analyzed using the Maxqda 2020 qualitative data analysis program, and survey data were analyzed using SPSS version 25.0.
    RESULTS: Over the past 2 decades, there has been a gradual shift from vaginal deliveries to cesarean deliveries in cases involving breech presentation, macrosomic fetus, twin pregnancy, and vacuum use. While medicolegal concerns are undeniable, the prevalent belief among obstetricians that cesarean delivery is safer than vaginal delivery significantly influences this trend. Comparatively, young obstetricians often complete their residency training without acquiring sufficient knowledge and skills in vaginal delivery.
    CONCLUSIONS: Young obstetricians currently lack adequate experience in managing vaginal deliveries for breech presentation, macrosomic fetus, twin pregnancy, and vacuum use. This experience is at risk of disappearing entirely within the next decade as senior obstetricians retire. Policymakers should take this into consideration when shaping future healthcare policies.
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  • 文章类型: Case Reports
    晚期早产妊娠的附件囊肿扭转很少见,但它经常导致继发性子宫收缩。因此,尽管没有产科适应症,但由于术后早期分娩的可能性,决定同时进行剖宫产至关重要。这里,我们报告一例妊娠34周时附件扭转急诊手术治疗,然后是足月阴道分娩,以及文献综述。一名31岁的primigravida在妊娠34周零四天时出现右下腹痛,被送往急诊科。进行了紧急剖腹手术以实现足月分娩,怀疑右卵巢囊肿扭转没有胎儿窘迫的迹象。七氟醚全身麻醉优于脊髓麻醉,考虑切口高度。患者被放置在手术台上的左侧卧位,以确保适当的可视化并保持子宫循环。在超声引导下做一个4厘米的横向皮肤切口,揭示了正下方扭曲的右输卵管旁囊肿。囊肿被切除了,扭转得到了缓解。术后进展顺利,自然分娩发生在妊娠39周零6天,导致40周时阴道分娩。这种情况表明,即使是晚期早产附件扭转也可以通过适当的手术技术安全地管理。允许随后的学期阴道分娩。
    Adnexal cyst torsion in late preterm pregnancies is rare, but it frequently causes secondary uterine contractions. Thus, deciding on performing a simultaneous cesarean section due to the potential for early postoperative labor onset is crucial despite no obstetric indications. Here, we report a case of adnexal torsion at 34 weeks of gestation treated with emergency surgery, followed by a full-term vaginal delivery, along with a literature review. A 31-year-old primigravida at 34 weeks and four days of gestation presented to the emergency department with right lower abdominal pain. An emergency laparotomy was performed to achieve term delivery, suspecting right ovarian cyst torsion without signs of fetal distress. General anesthesia with sevoflurane was selected over spinal anesthesia, considering the incision height. The patient was placed in the left lateral decubitus position on the operating table to ensure proper visualization and maintain uterine circulation. A 4-cm transverse skin incision was made under ultrasound guidance, revealing the twisted right paratubal cyst immediately beneath. The cyst was excised, and the torsion was relieved. The postoperative course was uneventful, and spontaneous labor occurred at 39 weeks and six days of gestation, resulting in a vaginal delivery at 40 weeks. This case demonstrates that even late preterm adnexal torsion can be managed safely with appropriate surgical techniques, allowing for a subsequent term vaginal delivery.
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  • 文章类型: Journal Article
    在气管造口的女性中自发阴道分娩很少见,有关这种情况的文献也非常有限。因此,如果没有医学或产科禁忌症,这可能有助于考虑将足月阴道分娩作为此类患者的选择。我们介绍了一名来自印度南部泰米尔纳德邦的24岁女性患者,继发于声门下狭窄的气管造口术,在妊娠38周时到耳鼻咽喉科就诊,以了解足月阴道分娩的可能性。由于患者产科病史顺利,并且没有阴道分娩的医学或产科禁忌症,建议患者进行包括Valsalva动作在内的呼吸练习,并密切随访.患者在妊娠39周零5天足月分娩,在一组高级医生的帮助下,自发阴道分娩,没有并发症。可以在气管造口的女性中尝试阴道分娩,在没有任何医学或产科禁忌症的情况下,如果病人有动力,我们有一个来自所有相关部门的专家医生小组。
    Spontaneous vaginal delivery in a tracheostomised woman is rare and literature concerning the same is also very limited, hence this might help in considering vaginal delivery at term as an option in such patients when there are no medical or obstetrical contraindications for the same. We present a case of a 24 years female patient hailing from Tamil Nadu in South India, who was tracheostomised secondary to subglottic stenosis, presented to Otorhinolaryngology department at thirty-eight weeks of gestation to know the possibility of a vaginal delivery at term. Since the patient had an uneventful obstetrical history and no medical or obstetrical contraindications for a vaginal delivery, patient was advised breathing exercises including Valsalva manoeuvre and kept under close follow up. Patient went to labor at term at thirty-nine weeks and five days of gestation, and with the help of a panel of senior doctors underwent spontaneous vaginal delivery with no complications. Vaginal delivery can be attempted in tracheostomised women, in the absence of any medical or obstetrical contra indications, if the patient is motivated and we have a panel of expert doctors from all concerned departments.
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  • 文章类型: Journal Article
    本研究旨在评估氨甲环酸(TXA)在预防产后出血(PPH)的效果,这些产后出血(PPH)的风险因素已确定在中国进行阴道分娩的妇女。
    这个前景,随机化,开放标签,盲法终点(PROBE)试验纳入了2258名接受阴道分娩的具有一种或多种PPH危险因素的女性.参与者以1:1的比例随机分配,在婴儿分娩后立即接受1gTXA或安慰剂的血管内输注。评估的主要结果是PPH的发生率,定义为分娩后24小时内失血≥500mL,而重度PPH被认为是次要结局,并定义为24小时内总失血≥1000mL。
    2245个人(99.4%)可以随访他们的主要结果。TXA组1128名妇女中有186名发生PPH,安慰剂组1117名妇女中有215名发生PPH(16.5%vs.19.2%;RR,0.86;95%CI,0.72至1.02;p=0.088)。关于与疗效相关的次要结果,TXA组的女性重度PPH的发生率明显低于安慰剂组(2.7%vs.5.6%;RR,0.49;95%CI,0.32至0.74;p=0.001;调整后p=0.002)。同样,使用额外的子宫收缩剂显著减少(7.8%vs.15.6%;RR,0.50;95%CI,0.39至0.63;p<0.001;调整后p=0.001)。两组在分娩后30天内均未发生血栓栓塞事件和孕产妇死亡。
    在有PPH危险因素的总人口中,与安慰剂相比,阴道分娩后给予TXA并未导致PPH发生率的统计学显著降低;它与重度PPH的发生率显著降低相关.
    在阴道分娩中有危险因素的妇女中,预防性给予TXA并没有显著降低PPH的发生率。预防性使用TXA可能有助于降低严重PPH的发生率。
    UNASSIGNED: This study aimed to evaluate the effects of tranexamic acid (TXA) in preventing postpartum haemorrhage (PPH) among women with identified risk factors for PPH undergoing vaginal delivery in China.
    UNASSIGNED: This prospective, randomized, open-label, blinded endpoint (PROBE) trial enrolled 2258 women with one or more risk factors for PPH who underwent vaginal delivery. Participants were randomly assigned in a 1:1 ratio to receive an intravascular infusion of 1 g TXA or a placebo immediately after the delivery of the infant. The primary outcome assessed was the incidence of PPH, defined as blood loss ≥500 mL within 24 h after delivery, while severe PPH was considered as a secondary outcome and defined by total blood loss ≥1000 mL within 24 h.
    UNASSIGNED: 2245 individuals (99.4%) could be followed up to their primary outcome. PPH occurred in 186 of 1128 women in the TXA group and in 215 of 1117 women in the placebo group (16.5% vs. 19.2%; RR, 0.86; 95% CI, 0.72 to 1.02; p = 0.088). Regarding secondary outcomes related to efficacy, women in the TXA group had a significant lower rate of severe PPH than those in the placebo group (2.7% vs. 5.6%; RR, 0.49; 95% CI, 0.32 to 0.74; p = 0.001; adjusted p = 0.002). Similarly, there was a significant reduction in the use of additional uterotonic agents (7.8% vs. 15.6%; RR, 0.50; 95% CI, 0.39 to 0.63; p < 0.001; adjusted p = 0.001). No occurrence of thromboembolic events and maternal deaths were reported in both groups within 30 days after delivery.
    UNASSIGNED: In total population with risk factors for PPH, the administration of TXA following vaginal delivery did not result in a statistically significant reduction in the incidence of PPH compared to placebo; however, it was associated with a significantly lower incidence of severe PPH.
    Prophylactic administration of TXA did not yield a statistically significant reduction in the incidence of PPH among women with risk factors in vaginal deliveries.Prophylactic use of TXA may help to reduce the incidence of severe PPH.
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