背景:营养已成为影响几种癌症预后的重要参数。然而,其对膀胱癌(BC)结局的影响尚不清楚.这篇综述探讨了三种常用的营养指数之间的关联,即,预后营养指数(PNI),控制营养状况(CONUT),老年营养风险指数(GNRI)和BC的结局。
方法:PubMed,中部,Scopus,WebofScience,Embase,和谷歌学者在2023年4月13日之前发表的研究中进行了探索。汇集研究数据,以检查PNI,CONUT,或GNRI和总生存期(OS)和无复发生存期(RFS)。
结果:共纳入13项研究。荟萃分析表明,BC患者低PNI与高PNI患者的OS明显较差(风险比[HR]:1.71;95%置信区间[CI]:1.37,2.14;I2=0%)。该结果在各种亚组分析中仍然显著。然而,PNI和RFS之间无相关性(HR:1.22;95%CI:0.67,2.24;I2=84%).Meta分析显示,CONUT评分高的患者的OS(HR:2.43;95%CI:1.82,3.25;I2=0%)和RFS(HR:2.90;95%CI:2.10,4.01;I2=0%)均显著较差。有关GNRI的数据很少且相互矛盾。
结论:有限的数据显示PNI和CONUT可预测BC的结局。低PNI与不良操作系统有关,而高CONUT与不良的OS和RFS相关。关于GNRI的数据太少,无法得出结论。需要进一步的研究来补充结果。
BACKGROUND: Nutrition has become an important parameter influencing the prognosis of several cancers. However, its impact on outcomes for bladder cancer (BC) is still unclear. This
review examines the association between three commonly used nutritional indices, namely, the prognostic nutritional index (PNI), controlling nutritional status (CONUT), and the geriatric nutritional risk index (GNRI) and outcomes of BC.
METHODS: PubMed, CENTRAL, Scopus, Web of Science, Embase, and Google Scholar were explored for studies published up to April 13, 2023. Data from studies were pooled to examine the association between PNI, CONUT, or GNRI and overall survival (OS) and recurrence-free survival (RFS).
RESULTS: Thirteen studies were included. Meta-analysis demonstrated significantly poor OS with low PNI versus high PNI in BC patients (hazard ratio [HR]: 1.71; 95% confidence interval [CI]: 1.37, 2.14; I2 = 0%). This result remained significant in various subgroup analyses. However, no association was noted between PNI and RFS (HR: 1.22; 95% CI: 0.67, 2.24; I2 = 84%). Meta-analysis showed that patients with high CONUT scores had significantly poor OS (HR: 2.43; 95% CI: 1.82, 3.25; I2 = 0%) as well as RFS (HR: 2.90; 95% CI: 2.10, 4.01; I2 = 0%). Data on GNRI were scarce and conflicting.
CONCLUSIONS: Limited data show that PNI and CONUT are predictive of outcomes in BC. Low PNI was associated with poor OS, while high CONUT was associated with poor OS and RFS. Data on GNRI are too scarce to obtain conclusions. Further studies are needed to supplement the results.