■原因不明的复发性妊娠丢失（RPL）占RPL患者的50％以上。胰岛素抵抗（IR）是原因不明的RPL的潜在原因。
■评估沙特女性胰岛素抵抗（IR）与无法解释的RPL之间的关系。
■这是一个单中心，在沙特阿拉伯东部省的一家三级医院进行的病例对照研究。研究小组由患有无法解释的RPL的沙特女性组成，而对照组的沙特女性至少有一个活产，没有RPL。采集血样以确定空腹血糖(FG)和空腹胰岛素(FI)水平。排除患有糖尿病和多囊卵巢综合征的女性。胰岛素抵抗指数（HOMA-IR）值≥3的稳态模型评估被认为是IR。
■研究组和对照组包括43名和56名女性，分别。在群体之间，平均年龄（病例：37.9±5.4岁；对照组：32.2±5.9岁；P<0.0001）和平均BMI（病例：31.5±6.0；对照组：26.1±2.8；P<0.0001）差异有统计学意义。对照组FG水平略高（90.9mg/dLvs88.7mg/dL；P=0.068）。研究组的FI水平明显较高（16.33μU/mLvs.6.17μU/mL；P<0.0001）。≥3的HOMA-IR在研究组(n=22;51.2%)明显高于对照组(4;7.1%)(P<0.0001)。在调整了年龄和BMI后，发现IR≥3与无法解释的RPL独立相关（aOR：13.2；95％CI：3.77-46.36）。
■这项研究表明，与没有RPL病史的人相比，患有无法解释的RPL的沙特女性的空腹胰岛素水平和胰岛素抵抗水平明显更高。因此,建议评估RPL女性的IR.
UNASSIGNED: Unexplained recurrent pregnancy loss (RPL) accounts for >50% of the patients with RPL. Insulin resistance (IR) is a potential cause of
unexplained RPL.
UNASSIGNED: To evaluate the relationship between insulin resistance (IR) and unexplained RPL among Saudi women.
UNASSIGNED: This is a single-center,
case-control study conducted at a tertiary hospital in the Eastern Province of Saudi Arabia. The study group comprised Saudi women with unexplained RPL, while the control group had Saudi women with at least one live birth and no RPL. Blood samples were taken to determine the fasting glucose (FG) and fasting insulin (FI) levels. Women with diabetes mellitus and polycystic ovarian syndrome were excluded. A homeostatic model assessment of insulin resistance index (HOMA-IR) value ≥3 was considered as IR.
UNASSIGNED: The study and control groups comprised 43 and 56 women, respectively. Between the groups, there was a significant difference in the mean age (
case: 37.9 ± 5.4 years; control: 32.2 ± 5.9 years; P < 0.0001) and the mean BMI (
case: 31.5 ± 6.0; control: 26.1 ± 2.8; P < 0.0001). FG level was slightly higher in the control group (90.9 mg/dL vs 88.7 mg/dL; P = 0.068). FI level was significantly higher in the study group (16.33 μU/mL vs. 6.17 μU/mL; P < 0.0001). HOMA-IR of ≥3 was significantly more common in the study group (n = 22; 51.2%) than the control group (4; 7.1%) (P < 0.0001). After adjusting for age and BMI, IR ≥3 was found to be independently associated with unexplained RPL (aOR: 13.2; 95% CI: 3.77-46.36).
UNASSIGNED: This study showed that Saudi women with unexplained RPL had significantly higher levels of fasting insulin and insulin resistance than those without a history of RPL. Therefore, it is recommended to assess IR in women with RPL.
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