SUMO系统是真核细胞用于响应应激的快速动态翻译后机制。植物细胞经历底物的超SUMO化,以响应应力,如热,乙醇,和干旱。许多SUMO化蛋白位于细胞核中,磺酰化改变许多核过程。SUMO蛋白酶通过产生游离的SUMO在SUMO循环中发挥两个关键功能;它们在调节SUMO循环中具有重要作用。通过切割SUMO去SUMO化的蛋白质,它们提供蛋白质被SUMO化的特异性。这篇综述总结了植物SUMO蛋白酶描述其催化活性的广泛文献,域和结构,进化,本地化,以及对压力的反应,并突出未来潜在的新研究领域。
The SUMO system is a rapid dynamic post-translational mechanism employed by eukaryotic cells to respond to stress. Plant cells experience hyperSUMOylation of substrates in response to stresses such as heat, ethanol, and drought. Many SUMOylated proteins are located in the nucleus, SUMOylation altering many nuclear processes. The SUMO proteases play two key functions in the SUMO cycle by generating free SUMO; they have an important role in regulating the SUMO cycle, and by cleaving SUMO off SUMOylated proteins, they provide specificity to which proteins become SUMOylated. This
review summarizes the broad literature of plant SUMO proteases describing their catalytic activity, domains and structure, evolution, localization, and response to stress and highlighting potential new areas of research in the future.