未经证实:缺血性卒中是结核性脑膜炎(TBM)患者的常见并发症。然而,TBM患者缺血性卒中的危险因素尚未完全了解,尤其是那些没有常规血管危险因素的患者。本研究的目的是探讨结核性脑膜炎相关性缺血性卒中(TBMRIS)的临床特征和独立危险因素。
UNASSIGNED:纳入2010年7月至2020年7月无常规血管危险因素的急性缺血性卒中的结核性脑膜炎患者作为TBMRIS组。招募仅患有结核性脑膜炎的患者作为对照组(TMB组)。人口特征,临床表现,收集脑脊液(CSF)检查,多因素logistic回归分析TBMRIS的独立危险因素。
未经批准:共纳入70例TBMRIS患者和70例TMB患者。大多数(82.86%)的TBMRIS患者在诊断为结核性脑膜炎后3个月内出现缺血性卒中事件。多因素logistic回归分析显示红细胞分布宽度(RDW-CV)、平均血小板体积(MVP),C反应蛋白(CRP),CSF葡萄糖和改良的ResearchCouncilII级(MRCII级)是TBRIS的独立危险因素。鉴定模型的AUC为0.808,灵敏度为68.60%,特异性为84.30%。
未经批准:这项研究表明,RDW-CV,MVP,CRP,CSF葡萄糖和MRCII级是TBMRIS的潜在独立危险因素。在这项研究中建立的识别模型可能有助于监测处于发展TBMRIS的高风险的TBM患者。
UNASSIGNED: Ischemic stroke is a common complication in patients with tubercular meningitis (TBM). However, the risk factors for Ischemic stroke in TBM patients are not fully understood, especially in those patients without conventional vascular risk factors. The aim of the present
study was to explore the clinical features and independent risk factors for tubercular meningitis-related Ischemic stroke (TBMRIS).
UNASSIGNED: Tubercular meningitis patients with acute Ischemic stroke without conventional vascular risk factors were recruited between July 2010 and July 2020 as the TBMRIS group. Patients who solely had tubercular meningitis were recruited as the control group (TMB group). Demographic characteristics, clinical presentations, and cerebrospinal fluid (CSF) examinations were collected, and multiple logistic regression analysis was applied to analyse the independent risk factors for TBMRIS.
UNASSIGNED: A total of 70 TBMRIS patients and 70 TMB patients were enrolled. Most (82.86%) of the TBMRIS patients experienced Ischemic stroke events within 3 months after the diagnosis of tubercular meningitis. The multiple logistic regression analysis revealed that variation in red blood cell distribution width (RDW-CV), mean platelet volume (MVP), C-reactive protein (CRP), CSF glucose and Modified Research Council Grade II (MRC Grade II) were independent risk factors for TBRIS. The AUC of the identification model was 0.808, with a sensitivity of 68.60% and a specificity of 84.30%.
UNASSIGNED: This
study revealed that RDW-CV, MVP, CRP, CSF glucose and MRC Grade II are potential independent risk factors for TBMRIS. The identification model established in this
study may help monitor TBM patients who are at high risk of developing TBMRIS.