背景:到目前为止,高密度脂蛋白胆固醇(HDL-C)水平与死亡率呈U型关系.此外,高HDL-C水平会增加患多种疾病的风险。然而,关于高HDL-C水平人群的特征的数据很少。这项研究的目的是评估高HDL-C水平患者的人口统计学和特征,并将其特征与正常和低HDL-C组进行比较。
方法:作为横截面,配对病例对照研究,共有510例2型糖尿病(T2D)患者纳入研究,并根据HDL-C浓度分为3组.研究组的年龄和性别相匹配。设计了限制三次样条(RCS)曲线来评估高度之间的关系,血压,甘油三酯,和维生素D浓度具有高HDL-C水平的可能性。此外,进行了小提琴图,以说明各组中连续变量的分布。
结果:这项研究表明,高HDL-C(超过70mg/dL)与低HDL-C(男性低于40mg/dL,女性低于50mg/dL)相比,与身高显着相关(OR0.918,95%CI0.866-0.974),收缩压(SBP)(0.941,0.910-0.972),维生素D(0.970,0.941-0.999),和甘油三酯(0.992,0.987-0.998)血清浓度。进一步的分析研究表明,与所需的HDL-C水平相比,HDL-C水平较高(男性40≤HDL-C水平<70,女性50≤HDL-C水平<70)与SPB值大于130mmHg成反比。此外,与正常HDL-C水平相比,足够的维生素D水平(高于20ng/ml)可使HDL-C升高的几率降低0.349倍.
结论:足够的维生素D水平,SPB值高于130mmHg,以及增加的甘油三酯水平,与高HDL水平呈负相关。然而,较高的身高值与高HDL的可能性降低相关.
BACKGROUND: So far, high-density lipoprotein cholesterol (HDL-C) levels and mortality were shown to have a U-shaped relationship. Additionally, high HDL-C levels increase the risk of developing a variety of diseases. However, a paucity of data exists regarding the characteristics of people with high HDL-C levels. The aim of this study was to assess the demographics and characteristics of patients with high HDL-C levels and compare their features with normal and low HDL-C groups.
METHODS: As a cross-sectional, matched
case-control study, a total of 510 patients with type 2 diabetes (T2D) were enrolled in the study and categorized into three matched groups according to their HDL-C concentrations. The studied groups were matched by their age and gender. Restricted cubic spline (RCS) curves were designed to evaluate the relationship between height, blood pressure,
triglyceride, and vitamin D concentrations with the probability of having high HDL-C levels. Furthermore, violin plots were conducted to illustrate the distribution of continuous variables within each group.
RESULTS: This study showed that having high HDL-C (more than 70 mg/dL) compared to having low HDL-C (less than 40 mg/dL in men and 50 mg/dL in women) was significantly associated with height (OR 0.918, 95% CI 0.866-0.974), systolic blood pressure (SBP) (0.941, 0.910-0.972), vitamin D (0.970, 0.941-0.999), and
triglyceride (0.992, 0.987-0.998) serum concentrations. Further analysis investigated that having high HDL-C levels compared to desired HDL-C levels (40 ≤ HDL-C levels < 70 in men and 50 ≤ HDL-C levels < 70 in women) was inversely associated with having SPB values greater than 130 mmHg. Besides, sufficient vitamin D levels (above 20 ng/ml) could 0.349 times decrease the odds of having high HDL-C versus normal HDL-C levels.
CONCLUSIONS: Sufficient vitamin D levels, SPB values higher than 130 mmHg, as well as increased
triglyceride levels, were inversely associated with having high HDL levels. However, higher height values were associated with a decreased likelihood of having high HDL.