背景:甲真菌病是指甲单位的真菌感染。指甲装置的解剖和生理特征要求长期治疗以实现完全治愈。
目的:该项目的主要目标是根据甲癣临床评分指数(SCIO)研究几种甲癣治疗方案的有效性。
方法:本研究纳入133例甲癣患者,通过KOH显微镜和培养诊断。根据疾病的严重程度,患者分为SCIO值6-9和12-16组.根据给定的治疗方案,将这些组随机分为5个亚组:氟康唑150mg,每周1次,伊曲康唑持续治疗,伊曲康唑脉冲疗法,特比萘芬250毫克/天,和特比萘芬+环吡酮8%漆,分别。在48周结束时评估治愈率。
结果:根据上述方案获得的固化速率为:92.30%,81.81%,83.33%,90.90%,100%,分别为SCIO值6-9的患者组。在SCIO值12-16的患者中,治愈率如下:78.57%,78.57%,75%,80%,和86.66%。
结论:本研究中采用的五种治疗方案之间的治愈率没有统计学上的显着差异。在具有高SCIO值的患者中,预期治愈率降低。
BACKGROUND: Onychomycosis is a fungal infection of the nail unit. Anatomical and physiological characteristics of the nail apparatus impose the need for long-term treatment to achieve complete cure.
OBJECTIVE: The main goal of this project is to
study the effectiveness of several treatment protocols for onychomycosis based on Scoring Clinical Index for Onychomycosis (SCIO).
METHODS: The
study included 133 patients with onychomycosis, diagnosed by KOH microscopy and culture. Based on disease severity, patients were grouped into groups with SCIO values: 6-9, and 12-16. These groups were randomly subdivided to 5 subgroups according to the given treatment protocols: fluconazole 150 mg 1x weekly, itraconazole continual therapy, itraconazole pulse therapy, terbinafine 250 mg/d, and terbinafine + ciclopirox 8% lacquer, respectively. The cure rate was evaluated at the end of 48 week.
RESULTS: The obtained cure rates according to the above mentioned protocols were: 92.30%, 81.81%, 83.33%, 90.90%, and 100%, respectively for groups of patients with SCIO values 6 - 9. Within patients with SCIO values 12-16, were achieved cure rates as follows: 78.57%, 78.57%, 75%, 80%, and 86.66%.
CONCLUSIONS: There was no statistically significant difference in cure rate between five treatment protocols applied in this
study. In patients with high SCIO values is expected a decrease in cure rate.