中风后脑组织急性损伤后的病变生长,蛛网膜下腔出血和创伤性脑损伤是一个重要的问题和有希望的治疗干预新的目标领域。扩散的去极化或病灶周围的去极化波被证明是病灶持续生长的重要因素之一。在这篇简短的评论中,我们讨论了SD形成事件的病理生理学,并尝试列出在偏头痛等神经系统疾病中检测到的发现,中风,蛛网膜下腔出血和创伤性脑损伤在人类以及实验研究。强调了药物和非药物治疗策略,并讨论了未来的方向和研究局限性。
Lesion growth following acutely injured brain tissue after stroke, subarachnoid hemorrhage and traumatic brain injury is an important issue and a new target area for promising therapeutic interventions. Spreading depolarization or peri-lesion depolarization waves were demonstrated as one of the significant contributors of continued lesion growth. In this short
review, we discuss the pathophysiology for SD forming events and try to list findings detected in neurological disorders like migraine, stroke, subarachnoid hemorrhage and traumatic brain injury in both human as well as experimental studies. Pharmacological and non-pharmacological treatment strategies are highlighted and future directions and research limitations are discussed.