人类多态性可能导致SARS-CoV-2感染易感性和COVID-19结果(无症状表现,严重的COVID-19,死亡)。我们的目的是评估IFITM3,FURIN,使用荟萃分析,ACE1和TNF-α遗传变异具有两种表型。书目搜索是在PubMed和Scielo数据库上进行的,涵盖了2022年2月8日之前发布的报告。两名独立研究人员使用Q-Genie工具检查了研究质量。使用Mantel-Haenszel加权均值方法,在固定效应和随机效应模型下结合比值比.27项研究包括在系统评价中(5项与IFITM3,2项与Furin,三个与TNF-α,和17与ACE1)和22在荟萃分析中(IFITM3n=3,TNF-α,和ACE1n=16)。荟萃分析表明1)ACE1rs4646994与易感性无关联,2)ACE1rs4646994和无症状COVID-19,3)IFITM3rs12252和ICU住院,和4)TNF-αrs1800629和死亡。另一方面,发现ACE1rs4646994与COVID-19严重程度相关的显著结果(11项研究,692例严重病例,和1,433个非严重对照)。ACE1rs4646994缺失等位基因显示严重表现的几率增加(OR:1.45;95%CI:1.26-1.66)。纯合子缺失是一个危险因素(OR:1.49,95%CI:1.22-1.83),而纯合插入具有保护作用(OR:0.57,95%CI:0.45-0.74)。需要进一步的报告来验证这种对具有不同种族背景的人群的影响。系统审查注册:https://www。crd.约克。AC.英国/繁荣显示器_记录。php?ID=CRD42021268578,标识符CRD42021268578。
Human polymorphisms may contribute to SARS-CoV-2 infection susceptibility and COVID-19 outcomes (asymptomatic presentation, severe COVID-19, death). We aimed to evaluate the association of IFITM3, FURIN, ACE1, and TNF-α genetic variants with both phenotypes using meta-analysis. The bibliographic search was conducted on the PubMed and Scielo databases covering reports published until February 8, 2022. Two independent researchers examined the study quality using the Q-Genie tool. Using the Mantel-Haenszel weighted means method, odds ratios were combined under both fixed- and random-effect models. Twenty-seven studies were included in the systematic
review (five with IFITM3, two with Furin, three with TNF-α, and 17 with ACE1) and 22 in the meta-analysis (IFITM3 n = 3, TNF-α, and ACE1 n = 16). Meta-analysis indicated no association of 1) ACE1 rs4646994 and susceptibility, 2) ACE1 rs4646994 and asymptomatic COVID-19, 3) IFITM3 rs12252 and ICU hospitalization, and 4) TNF-α rs1800629 and death. On the other hand, significant results were found for ACE1 rs4646994 association with COVID-19 severity (11 studies, 692 severe cases, and 1,433 nonsevere controls). The ACE1 rs4646994 deletion allele showed increased odds for severe manifestation (OR: 1.45; 95% CI: 1.26-1.66). The homozygous deletion was a risk factor (OR: 1.49, 95% CI: 1.22-1.83), while homozygous insertion presented a protective effect (OR: 0.57, 95% CI: 0.45-0.74). Further reports are needed to verify this effect on populations with different ethnic backgrounds. Systematic
Review Registration: https://www.crd.york.ac.uk/prosperodisplay_record.php?ID=CRD42021268578, identifier CRD42021268578.