目前还没有很好地理解铪(Hf)在生物过程中的直接作用或其在生物中的关键功能。与氧气等关键元素不同,碳,氢气,和氮,这是生命所必需的,已知Hf不具有任何生物活性或功能。必须承认科学研究正在进行中,并且可能已经取得了新的发现。本系统综述旨在汇总和分析讨论Hf金属生物医学应用的研究。本系统审查是按照系统审查和荟萃分析(PRISMA)声明的首选报告项目指南进行的。使用了以下搜索策略:两名独立研究人员在包括PubMed在内的数据库中进行了电子搜索,Embase,Cochrane系统评价数据库,谷歌学者。搜索一直进行到2023年8月,使用医学主题词(MeSH)术语“过渡元素”,\"\"铪,“和”生物医学研究。\"布尔运算符\"AND\"和\"OR\"用于细化搜索。电子数据库,随着手搜索,共确定了38项研究。通过各种数据库搜索,共进行了38项研究,其中12个被排除为重复,和五个无法获得全文数据。然后根据纳入和排除标准对其余21篇全文进行资格评估,最后,本系统综述共纳入12项研究.在12项选定的研究中,6人接受癌症相关的靶向放疗或放化疗,五个是骨骼或磷灰石形成能力,其中之一是治疗炎症性肠病。常见的结果指标包括细胞增殖,成骨细胞形成,放疗强化,和免疫疗法。这篇综述概述了Hf金属的生物医学用途的全貌,一个过渡元素,作为一种有效的生物材料。总之,这个过渡元素,Hf,在生物医学领域有一定的前景,特别关注癌症放射治疗和成骨能力。
The direct engagement of hafnium (Hf) in biological processes or its critical function in living things is not well understood as of now. Unlike key elements like oxygen, carbon, hydrogen, and nitrogen, which are necessary for life, Hf is not known to have any biological activities or functions. It is essential to acknowledge that scientific research is ongoing and that new findings may have been made. This systematic
review aimed to aggregate and analyze the studies that discuss biomedical applications of Hf metal. This systematic
review was conducted following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement. The following search strategy was used: two independent researchers conducted electronic searches in databases including PubMed, Embase, Cochrane Database of Systematic Reviews, and Google Scholar. The search was conducted up to August 2023 using the Medical Subject Headings (MeSH) terms \"transition elements,\" \"hafnium,\" and \"biomedical research.\" Boolean operators \"AND\" and \"OR\" were used to refine the search. Electronic databases, along with hand searches, identified a total of 38 studies. The various database searches resulted in a total of 38 studies, of which 12 were excluded as duplicates, and five were unavailable for full-text data. The remaining 21 full-text articles were then assessed for their eligibility based on the inclusion and exclusion criteria, and finally, a total of 12 studies were included in the present systematic
review. Among the 12 chosen studies, six were on cancer-related targeted radiotherapy or chemoradiotherapy, five were on bone or apatite-forming capabilities, and one was on the treatment of inflammatory bowel disease. The common outcome measures included cell proliferation, osteoblast formation, radiotherapy intensification, and immunotherapy. This
review outlines an overall picture of the biomedical uses of Hf metal, a transition element, as a potent biomaterial. In conclusion, this transition element, Hf, has some promising scope in the fields of biomedicine, with a special focus in terms of cancer radiotherapy and osteogenic capabilities.