选择性激光小梁成形术(SLT)能量剂量反应的文献综述发现,眼内压(IOP)降低与总能量或脉冲能量之间没有明确的关系。种族,色素沉着,或应用程序模式。
SLT是一种安全有效的降低眼压的治疗方法。尽管越来越多的证据表明其用作降低IOP的一线治疗具有优势,使用的SLT程序差异很大。本文献综述的目的是研究在已发表的文献中SLT能量与降低IOP的功效之间是否存在任何关系。
进行了文献综述,其中包括研究成功SLT治疗所需的能量水平的研究:关于角度色素沉着,种族或民族,和处理弧度。
没有迹象表明治疗中使用的较高(或较低)能量导致较大(或较小)的IOP降低。关于小梁网色素沉着的水平获得了类似的结果。在SLT中未发现种族与改变的剂量反应相关。有迹象表明,治疗整个360度,相对于较小的弧,可能有利于更多的眼压降低。发现SLT的IOP降低与局部药物提供的类似。
降低IOP所需的SLT最佳能量水平尚未确定,所有报告的脉冲能量导致类似的IOP降低。此外,关于在不同种族和不同程度的小梁网色素沉着中使用的最佳SLT能量剂量,也存在类似的结论性发现。该参数和上述每个因素需要进一步研究。
A literature
review of selective laser trabeculoplasty (SLT) energy dose-response found no definitive relationship between intraocular pressure (IOP) reduction with respect to total or pulse energy, race, pigmentation, or application pattern.
SLT is a safe and effective treatment for lowering IOP. Although evidence is mounting for the advantage of its use as a first-line treatment for IOP reduction, the SLT procedures in use vary widely. The purpose of this literature
review was to investigate whether there were any relationships between SLT energy and efficacy for lowering IOP in the published literature.
A literature
review was undertaken that included studies in which energy levels required for successful SLT treatment were investigated: in general, with respect to angle pigmentation, race or ethnicity, and treatment arc extent.
There was no indication that higher (or lower) energy used in the treatment leads to greater (or less) IOP reduction. Similar results were obtained regarding the level of trabecular meshwork pigmentation. Race was not found to be associated with altered dose response in SLT. There were indications that treating the full 360 degrees, as opposed to smaller arcs, could be beneficial for more IOP reduction. IOP reduction from SLT was found to be similar to that provided by topical medications.
The optimal energy level of SLT needed for IOP reduction has not yet been definitively established, with all reported pulse energies resulting in similar IOP reduction. Furthermore, similar lack of conclusive findings exists regarding optimal SLT energy dosage for use in different races and degrees of trabecular meshwork pigmentation. This parameter and each of the abovementioned factors requires further research.