背景:手术部位感染(SSI)和静脉血栓栓塞(VTE)与高负担和高成本相关,并且在全膝关节或髋关节置换术后被认为在很大程度上是可以预防的(TKA,THA)。当预防符合循证临床指南时,发生VTE和SSI的风险降低。然而,THA/TKA后VTE与抗生素预防临床指南依从性和患者报告结局指标(PROM)之间的关联尚不清楚.这项研究旨在探讨不符合VTE和抗生素指南建议的护理是否与手术后90天和365天的PROM(牛津髋关节/膝关节评分和EQ-5D指数评分)相关。
方法:这项前瞻性观察性研究包括公共和私人场所的大批量关节成形术,以及接受选择性初次THA/TKA的合格参与者。我们进行了多元线性回归和线性混合效应建模,以探索不遵守VTE和抗生素指南之间的关联。
结果:样本包括1838名参与者。VTE和抗生素指南的依从性分别为35%和13.2%。在调整后的建模中,不遵守VTE指南与90天牛津评分无关(β=-0.54,标准误差[SE]=0.34,p=0.112),但与较低(较差)365天牛津评分显着相关(β=-0.76,SE=0.29,p=0.009),在90天(β=-0.02SE=0.008,p=0.011)和365天(β=-0.03,SE=0.008,p=0.002)时,EQ-5D指数得分较低。.牛津和EQ-5D指数评分的变化在临床上并不重要。不遵守抗生素指南与90-(牛津:β=-0.45,标准误差[SE]=0.47,p=0.341;EQ-5D:β=-0.001,SE=0.011,p=0.891)或365天(牛津评分:β=-0.06,SE=0.41,p=0.880EQ-5D:β=-0.010,SE=0.012,p=0.383)的PROM无关。当将并发症纳入模型和线性混合效应模型中时,结果是一致的,其中保险业是随机效应。
结论:不遵守VTE预防指南,但不是抗生素指南,在365天时,牛津评分和EQ-5D指数评分与统计学上显著但无临床意义的差异相关。
BACKGROUND: Surgical site infection (SSI) and venous thromboembolism (VTE) are associated with high burden and cost and are considered largely preventable following total knee or hip arthroplasty (TKA, THA). The risk of developing VTE and SSI is reduced when prophylaxis is compliant with evidence-based clinical guidelines. However, the association between VTE and antibiotic prophylaxis clinical
guideline compliance and patient-reported outcome measures (PROMs) after THA/TKA is unknown. This study aims to explore whether care that is non-compliant with VTE and antibiotic
guideline recommendations is associated with PROMs (Oxford Hip/Knee Score and EQ-5D Index scores) at 90- and 365-days after surgery.
METHODS: This prospective observational study included high-volume arthroplasty public and private sites and consenting eligible participants undergoing elective primary THA/TKA. We conducted multiple linear regression and linear mixed-effects modelling to explore the associations between non-compliance with VTE and antibiotic guidelines, and PROMs.
RESULTS: The sample included 1838 participants. Compliance with VTE and antibiotic
guidelines was 35% and 13.2% respectively. In adjusted modelling, non-compliance with VTE
guidelines was not associated with 90-day Oxford score (β = - 0.54, standard error [SE] = 0.34, p = 0.112) but was significantly associated with lower (worse) 365-day Oxford score (β = - 0.76, SE = 0.29, p = 0.009), lower EQ-5D Index scores at 90- (β = - 0.02 SE = 0.008, p = 0.011) and 365-days (β = - 0.03, SE = 0.008, p = 0.002).. The changes in Oxford and EQ-5D Index scores were not clinically important. Noncompliance with antibiotic guidelines was not associated with either PROM at 90- (Oxford: β = - 0.45, standard error [SE] = 0.47, p = 0.341; EQ-5D: β = - 0.001, SE = 0.011, p = 0.891) or 365-days (Oxford score: β = - 0.06, SE = 0.41, p = 0.880 EQ-5D: β = - 0.010, SE = 0.012, p = 0.383). Results were consistent when complications were included in the model and in linear mixed-effects modelling with the insurance sector as a random effect.
CONCLUSIONS: Non-compliance with VTE prophylaxis
guidelines, but not antibiotic
guidelines, is associated with statistically significant but not clinically meaningful differences in Oxford scores and EQ-5D Index scores at 365 days.