双侧丘脑原发性胶质瘤是极为罕见的实体。预示着双丘脑神经胶质瘤的检查和诊断的症状学是多种多样的,并且在儿童和成人人群之间有所不同。在这里,我们介绍了一个63岁的女性患者,她表现为进行性步态失衡和疲劳,提示门诊脑部MRI,显着的显着扩张的双侧丘脑继发于非增强,T2加权流体衰减反转恢复(T2-FLAIR)明亮的双丘脑病变。患者接受了右丘脑病变的右额叶无框立体定向活检,免疫组织学表明具有胶质母细胞瘤(GBM)分子特征的高级间变性星形细胞瘤。患者的功能状态在诊断活检后的一个月内急剧下降,排除任何治疗,患者最终在没有进一步治疗的情况下接受了家庭临终关怀护理。这个案例详细介绍了一个非常罕见的肿瘤的临床处理,补充有关这种罕见疾病的进展和治疗的现有文献。
Bilateral thalamic primary gliomas are an exceedingly rare entity. Symptomology heralding a workup and diagnosis of bithalamic gliomas is diverse and varies between the pediatric and adult populations. Herein, we present a
case of a 63-year-old female patient who presented with progressive gait imbalance and fatigue, prompting an outpatient brain MRI, remarkable for marked expansion of the bilateral thalami secondary to non-enhancing, T2-weighted-fluid-attenuated inversion recovery (T2-FLAIR) bright bithalamic lesions. The patient underwent a right frontal frameless stereotactic biopsy of the right thalamic lesion, with immuno-histology indicating a high-grade anaplastic astrocytoma with molecular features of glioblastoma (GBM). The patient\'s functional status declined precipitously in the month following her diagnostic biopsy, precluding any therapy, and the patient ultimately pursued home hospice care without further treatment. This
case details the clinical management of a very rare tumor, supplementing the available literature on the progression and treatment of this rare disease.