这项全球合作的目的是通过EULAR滑膜炎研究组（ESSG）和OMERACT滑膜组织活检组，开发一套共识的项目，用于临床实践和转化研究中的滑膜活检分析。
通过改进的德尔菲法咨询参与者。在12个月内连续进行了三轮。成员们收到了一份书面问卷，其中包含分为两部分的项目。项目是根据范围审查确定和制定的。问卷的第一部分涉及临床实践中的滑膜活检，包括五个小节，第二部分是翻译研究，分为六个小节。要求每个参与者在5分的李克特量表上对每个项目进行评分。下一轮选择中位数得分高于3.5且一致性≥70％的项目。最后一轮于2017年6月在EULAR口头进行。
通过电子邮件联系了来自19个中心的27名参与者。来自17个中心的20名参与者回答。下一轮的反应率为100％。关于临床实践的第一部分，选择了20/44项（45.5%）。关于翻译研究的第二部分，最终选择了18/43项目（41.9％）。
我们在此提出了一组合意的分析项目，用于在临床实践和转化研究中进行的滑膜活检。
The aim of this global collaboration was to develop a consensual set of items for the analysis of synovial biopsies in clinical practice and translational research through the EULAR Synovitis Study Group (ESSG) and OMERACT Synovial Tissue Biopsy Group.
Participants were consulted through a modified Delphi method. Three sequential rounds occurred over 12 months. Members were sent a written questionnaire containing items divided into two parts. Items were identified and formulated based on a scoping review. The first part of the questionnaire referred to synovial biopsies in clinical practice including five subsections, and the second part to translational research with six subsections. Every participant was asked to score each item on a 5-point Likert scale. Items with a median score above 3.5 and a ≥ 70% agreement were selected for the next round. The last round was conducted orally at EULAR in June 2017.
Twenty-seven participants from 19 centers were contacted by email. Twenty participants from 17 centers answered. Response rates for next rounds were 100%. For the first part relating to clinical practice, 20/44 items (45.5%) were selected. For the second part relating to translational research, 18/43 items (41.9%) were selected for the final set.
We herein propose a consensual set of analysis items to be used for synovial biopsies conducted in clinical practice and translational research.
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