背景:腹膜假粘液瘤(PMP)是一种罕见的,进步,慢慢成长,对肿瘤了解不足,5年无进展生存率低至48%。它的特征是不同程度的恶性和粘液和凝胶状结构的产生。通常,腹膜假性黏液瘤的发展与阑尾黏液性肿瘤和其他胃肠道或卵巢黏液性肿瘤的破裂有关。我们文献综述的目的是确定腹膜假性黏液瘤的卵巢病因的各个方面。
方法:作者在2024年2月1日至2024年3月2日之间对以下数据库进行了广泛的文献检索:Scopus,牛津期刊,和Reaxys,并将研究结果总结为七个主要的临床和副临床情况。
结果:根据我们的研究,由卵巢原因引起的腹膜假性黏液瘤主要有以下几种情况:(1)粘液性囊腺瘤;(2)粘液性卵巢癌;(3)结肠癌伴卵巢转移;(4)卵巢原发性成熟囊性畸胎瘤的恶性转化;(5)阑尾黏液囊肿伴腹膜播散,模仿卵巢肿瘤伴腹膜癌;(6)黏液性交界性卵巢癌与卵巢内的关系(7)
结论:在我们的研究中,我们旨在全面概述腹膜假性黏液瘤的卵巢原因,包括它的流行病学,图像特征,症状,目前的治疗,和有前途的未来疗法,为了找到可行的解决方案,由于缺乏对这种分泌粘液的恶性疾病的了解会增加延迟诊断或失控恶化的风险。
BACKGROUND: Pseudomyxoma peritonei (PMP) is a rare, progressive, slowly growing, inadequately understood neoplasm with a 5-year progression-free survival rate of as low as 48%. It is characterized by varying degrees of malignancy and the production of mucinous and gelatinous structures. Typically, the development of pseudomyxoma peritonei is associated with the rupture of appendiceal mucinous tumors and other gastrointestinal or ovarian mucinous tumors. The goal of our literature
review was to identify various aspects that characterize the ovarian causes of pseudomyxoma peritonei.
METHODS: The authors performed an extensive literature search between 1 February 2024 and 2 March 2024 on the following databases: Pubmed, Scopus, Oxford Journals, and Reaxys, and the findings were summarized into seven main clinical and paraclinical situations.
RESULTS: According to our research, the main instances in which pseudomyxoma peritonei can be triggered by an ovarian cause are the following: (1) mucinous cystadenoma; (2) mucinous ovarian cancer; (3) colon cancer with ovarian metastasis; (4) malignant transformation of an ovarian primary mature cystic teratoma; (5) appendiceal mucocele with peritoneal dissemination mimicking an ovarian tumor with peritoneal carcinomatosis; (6) mucinous borderline tumor developing inside an ovarian teratoma; and (7) the association between a mucinous bilateral ovarian cancer and a colonic tumor.
CONCLUSIONS: In our study, we aimed to provide a comprehensive overview of the ovarian causes of pseudomyxoma peritonei, including its epidemiology, imagery characteristics, symptoms, current treatment, and promising future therapies, in the hopes of finding feasible solutions, as a lack of understanding of this mucus-secreting malignant disease increases the risk of delayed diagnosis or uncontrolled deterioration.