目的:副交感神经网络损伤导致面神经损伤,舌下神经节变性,舌下腺功能障碍,口干。在这项研究中,蛛网膜下腔出血(SAH)被认为是口干的原因。
方法:我们评估了23只杂交兔,包括5个对照(第1组,对照)。将1毫升血清盐水注射到5只动物的大脑池中(第2组)。SAH是通过将1mL自体血液注射到13只动物的大脑池中来诱导的(第3组)。诱导3周后处死动物。切除动物舌下神经节和舌下腺进行组织病理学检查。舌下神经节中退化细胞的数量,分泌性囊泡,使用所有理论质谱数据分析的顺序窗口采集来估计舌下腺中含有唾液成分的分泌颗粒。通过Mann-WhitneyU检验比较这些值。
结果:舌下腺分泌囊泡的数量为5.3±1.1×103(第1组),4.23±0.45×103(第2组),和1.56±0.22×103(第3组);舌下腺中含有唾液的分泌囊数为324±12.18(第1组),263±36.23(第2组),114±23.14(第3组);舌下神经节变性细胞数为11±3/mm3(第1组),98.43±15.54/mm3(第2组),和346±12.28/mm3(第3组)(P<0.05)。
结论:感染和干燥综合征等疾病的临床发现,无菌性脑膜炎,和SAH相似。然而,直到现在,尚未通过实验证明SAH会导致口干。发现SAH可能导致口干,可能会防止不必要的抗生素使用,并降低由于错误或延迟诊断而导致的发病率。
OBJECTIVE: Parasympathetic network damage results in facial nerve damage, sublingual ganglion degeneration, sublingual gland dysfunction, and dry mouth. In this
study, subarachnoid hemorrhage (SAH) was considered to be the cause of dry mouth.
METHODS: We assessed 23 hybrid rabbits, including 5 control (group 1, Control). One milliliter of serum saline was injected into the cisterna magna of 5 animals (group 2). SAH was induced by injecting 1 mL of autologous blood into the cisterna magna of 13 animals (group 3). The animals were killed after 3 weeks of induction. The animals\' sublingual ganglion and sublingual gland were excised for histopathological examination. The number of degenerated cells in the sublingual ganglion, secretory vesicles, and secretory granules in the sublingual gland that contain salivary components were estimated using Sequential Window Acquisition of All Theoretical Mass Spectra data analysis. The values were compared by the Mann-Whitney U-test.
RESULTS: The numbers of secretory vesicles in the sublingual gland were 5.3 ± 1.1 × 103 (group 1), 4.23 ± 0.45 × 103 (group 2), and 1.56 ± 0.22 × 103 (group 3); the numbers of secretory vesicles containing saliva in the sublingual gland were 324 ± 12.18 (group 1), 263 ± 36.23 (group 2), and 114 ± 23.14 (group 3); and the numbers of degenerated cells in the sublingual ganglion were 11 ± 3/mm3 (group 1), 98.43 ± 15.54/mm3 (group 2), and 346 ± 12.28/mm3 (group 3) (P < 0.05).
CONCLUSIONS: Clinical findings in infection and diseases such as Sjögren syndrome, aseptic meningitis, and SAH are similar. However, until now, SAH has not been demonstrated experimentally to cause dry mouth. Discovering that SAH might cause dry mouth might prevent unnecessary use of antibiotics and decrease morbidity due to the wrong or late diagnosis.