背景:2019年冠状病毒病(Covid-19)有许多不同的眼部表现。这项研究评估了该疾病和该疾病中使用的类固醇对眼部结构的影响。
目的:评估Covid-19和类固醇治疗严重感染对眼部结构和脉络膜厚度的影响。
方法:这项前瞻性研究包括76名因新冠肺炎住院患者的76只眼和30名健康志愿者对照组的30只眼。第一组包括35只眼,因接受类固醇治疗的中度至重度受累而住院,II组包括41只中度受累的眼睛,不需要类固醇治疗,第三组包括30只眼,年龄和性别相匹配的对照组.比较两组患者诊断后第3周和第3个月的眼科检查及影像学检查结果。
结果:所有参与者的平均年龄为40.2±6.1岁。在诊断Covid-19后的第三周,所有区域的脉络膜厚度(中心凹,鼻部,和时间)在I组中明显高于II组(对于所有,p<0.001)。此外,I组和II组的脉络膜厚度明显高于对照组(对于所有,p<0.001)。第三个月,所有组的脉络膜厚度值相似(对于中央凹,鼻部,和时间;分别为p=0.058,p=0.111,p=0.079)。
结论:我们的研究结果表明,Covid-19感染通过影响脉络膜层而导致脉络膜增厚,而类固醇治疗在急性期进一步增加了这种厚度。此外,这种增厚在三个月内逆转至正常水平表明该疾病对脉络膜的影响是可逆的。
BACKGROUND: Coronavirus disease 2019 (Covid-19) has many different ocular manifestations. This
study evaluates the effects of the disease and the steroid used in this disease on ocular structures.
OBJECTIVE: To evaluate the effects of Covid-19 and the steroids used in the treatment of severe infection on ocular structures and choroidal thickness.
METHODS: This prospective
study included 76 eyes of 76 patients who were hospitalized due to Covid-19 and 30 eyes of 30 healthy volunteering controls. Group I included 35 eyes who were hospitalized due to moderate-to-severe involvement that received steroid treatment, group II included 41 eyes with moderate involvement that did not require steroid treatment, and group III included 30 eyes with age- and gender-matched control subjects. Ophthalmological examination and imaging results of the patients obtained in the third week and third month after the diagnosis were compared between the groups.
RESULTS: Mean age of all participants was 40.2 ± 6.1 years. In the third week after the diagnosis of Covid-19, choroidal thickness in all regions (subfoveal, nasal, and temporal) was significantly greater in group I than in group II (for all, p<0.001). Moreover, choroidal thicknesses were significantly higher in group I and group II than in the control group (for all, p<0.001). In the third month, all the groups had similar choroidal thickness values (for subfoveal, nasal, and temporal; p=0.058, p=0.111, p=0.079, respectively).
CONCLUSIONS: Our findings showed that Covid-19 infection causes choroidal thickening by affecting the choroidal layer and that steroid treatment further increases this thickness in the acute period. In addition, the reversal of this thickening to the normal level within a period of three months indicates that the effect of the disease on the choroid is reversible.