UNASSIGNED:比较研究和随机对照试验(RCT)通常使用P(概率)值来传达其发现的统计学意义。P值是一个不完美的度量,然而,并且容易受到少数结果逆转的影响,以改变统计意义。包含脆弱性指数(FI)和脆弱性商(FQ)可能有助于解释研究的统计强度。
UNASSIGNED:这项研究的目的是检查比较单排至双排肩袖修复的研究的统计稳定性。据推测,这些研究的结果容易受到少数结果事件逆转的影响,通常少于失去随访的患者数量。
未经评估:系统评价;证据水平,3.
UNASSIGNED:我们分析了2000年至2021年在10种主要骨科期刊上发表的关于主要单排和双排肩袖修复的比较研究和随机对照研究。统计学显著性定义为P<0.05。每个结果的FI由改变显著性所必需的事件逆转的数量确定。通过将FI除以相应的样品大小来计算FQ。
未经评估:在筛选的4896项研究中,22项比较研究,其中10个是RCT,最终被纳入分析。共检查了74个结果。总的来说,中位数FI为2(四分位距[IQR],1-3),FQ中位数为0.035(IQR,0.020-0.057)。平均FI为2.55±1.29,平均FQ为0.043±0.027。在64%的结果中,FI低于失去随访的患者数量.)此外,81%的重要结果只需要一个单一的结果逆转就失去了意义。
UNASSIGNED:目前用于指导临床实践的研究中,有超过一半的患者失访率高于他们的FI。这些研究的结果应该在这些限制的背景下进行解释。未来的分析可能会受益于将FI和FQ纳入其统计分析。
UNASSIGNED: Comparative studies and randomized controlled trials (RCTs) often use the P (probability) value to convey the statistical significance of their findings. P values are an imperfect measure, however, and are vulnerable to a small number of outcome reversals to alter statistical significance. The inclusion of a fragility index (FI) and fragility quotient (FQ) may aid in the interpretation of a study\'s statistical strength.
UNASSIGNED: The purpose of this study was to examine the statistical stability of studies comparing single-row to double-row rotator cuff repair. It was hypothesized that the findings of these studies would be vulnerable to a small number of outcome event reversals, often fewer than the number of patients lost to follow-up.
UNASSIGNED: Systematic
review; Level of evidence, 3.
UNASSIGNED: We analyzed comparative studies and RCTs on primary single-row versus double-row rotator cuff repair that were published between 2000 and 2021 in 10 leading orthopaedic journals. Statistical significance was defined as a P < .05. The FI for each outcome was determined by the number of event reversals necessary to alter significance. The FQ was calculated by dividing the FI by the respective sample size.
UNASSIGNED: Of 4896 studies screened, 22 comparative studies, 10 of which were RCTs, were ultimately included for analysis. A total of 74 outcomes were examined. Overall, the median FI was 2 (interquartile range [IQR], 1-3), and the median FQ was 0.035 (IQR, 0.020-0.057). The mean FI was 2.55 ± 1.29, and the mean FQ was 0.043 ± 0.027. In 64% of outcomes, the FI was less than the number of patients lost to follow-up.) Additionally, 81% of significant outcomes needed just a single outcome reversal to lose their significance.
UNASSIGNED: Over half of the studies currently used to guide clinical practice have a number of patients lost to follow-up greater than their FI. The results of these studies should be interpreted within the context of these limitations. Future analyses may benefit from the inclusion of the FI and the FQ in their statistical analyses.