目的:为干燥综合征(SS)患者提供更好的先入为主和产前咨询。
方法:总共,台湾国民健康保险数据库和出生登记处确定了2004年至2014年期间的2100143例怀孕。确定了SS的母亲史,并比较有和没有SS的孕妇的数据。我们评估了胎儿-新生儿和产妇结局的比值比和95%置信区间。
结果:SS妇女怀孕449例,无SS妇女怀孕2,099694例。关于胎儿结局,静产的风险(比值比[OR]=2.14,95%置信区间[CI]=1.01-4.55),低出生体重(<2500g,OR=2.53,95%CI=1.92-3.33),小于胎龄(OR=2.03,95%CI=1.57-2.03),和胎儿窘迫(OR=1.72,95%CI=1.2-2.45)以及肺水肿的风险(OR=11.64,95%CI=1.62-83.48),休克(OR=6.07,95%CI=1.51-24.3),SS组的呼吸窘迫(OR=5.61,95%CI=1.39-22.6)高于非SS组。
结论:患有SS的妇女具有严重的胎儿-新生儿和产妇不良结局的风险,必须在受孕前接受产前咨询以了解所涉及的风险。
To provide better preconceptional and prenatal counselling to patients with sjögren syndrome (
SS).
In total, 2 100 143 pregnancies between 2004 and 2014 were identified in the Taiwan National Health Insurance database and birth registry. The maternal history of
SS was ascertained, and data were compared between pregnant women with and without
SS. We assessed the odds ratios and 95% CIs of fetal-neonatal and maternal outcomes.
There were 449 pregnancies in women with SS and 2 099 694 pregnancies in women without
SS. The risks of still birth [odds ratio (OR) = 2.14, 95% CI = 1.01, 4.55], low birth weight (<2500 g, OR = 2.53, 95% CI = 1.92, 3.33), small for gestational age (OR = 2.03, 95% CI = 1.57, 2.03) and fetal distress (OR = 1.72, 95% CI = 1.2, 2.45) as well as maternal risks of pulmonary oedema (OR = 11.64, 95% CI = 1.62, 83.48), shock (OR = 6.07, 95% CI = 1.51, 24.3) and respiratory distress (OR = 5.61, 95% CI = 1.39, 22.6) were higher in the SS group than in the non-
SS group.
Women with SS have significant risks of adverse fetal-neonatal and maternal outcomes and must undergo prenatal counselling to understand the risks involved before conception.