UNASSIGNED: Pancreatic Exocrine Insufficiency (PEI) is a possible cause of recurrent/persistent symptoms in celiac disease. Although pancreatic enzyme supplementation may be used to treat non-responsive celiac disease (NRCD) in clinical practice, clinical outcomes are variable and there is limited and low quality evidence to support this practice. The aim of this study was to assess the efficacy of pancreatic enzyme supplements (PES) for improvement of gastrointestinal symptoms in NRCD.
UNASSIGNED: Prospective, randomized, placebo-controlled, double-blind, cross-over trial in adults with NRCD examining Celiac Disease-Gastrointestinal Symptom Rating Scale (CeD-GSRS) scores on PES (pancrelipase co-administered with omeprazole) versus placebo (omeprazole only) during a 10-day treatment period. The study was registered under the clinical trials registry (https://clinicaltrials.gov/ number, NCT02475369) on 18 Jun 2015.
UNASSIGNED: Twelve participants (nine female) were included in the per-protocol analysis; one participant had low fecal elastase-1. Pancrelipase was not associated with significant change in CeD-GSRS compared to placebo (-0.03 versus -0.26; P = 0.366). There was a significant decrease in mean values of total CeD-GSRS scores (3.58 versus 2.90, P = 0.004), abdominal pain (2.92 versus 2.42, P = 0.009), and diarrhea sub-scores (3.44 versus 2.92, P = 0.037) during the run-in period with omeprazole.
UNASSIGNED: In this prospective, cross-over randomized, placebo-controlled study, PES did not improve symptoms in patients with NRCD. It is unclear whether this is a trial effect or related to administration of omeprazole.

UNASSIGNED: It is important to construct the sprue in a way that ensures that the mold gets an appropriate supply of metal at the right speed. Many manufacturers now offer sprue designs that have not been advocated in textbooks or publications for their normal use.
UNASSIGNED: The goal of this research was to compare the sprue design\'s marginal fit to that of the other designs.
UNASSIGNED: During this investigation, we attempted to see whether the fabrication of metal copings could be improved. Three sprue designs were used in this research for the assessment of casting accuracy: normal cylindrical, funnel-shaped, and cuboidal or flattened sprue forms.
UNASSIGNED: The mean marginal disparity of nickel-chromium (Ni-Cr) alloy copings made by three distinct brands was determined to be statistically insignificant.
UNASSIGNED: Within the limitation of the study, it was concluded that the marginal accuracy of metal copings fabricated with three different brands of Ni-Cr alloy did not reveal a statistically significant result. However, out of the three different sprue designs, that is, cylindrical, cuboidal, and funnel shape, the marginal accuracy of cylindrical and cuboidal sprue designs was found to be better than that of the funnel shape sprue design because the funnel shape sprue design is narrow at the point of attachment, thereby increasing the flow pressure and decreasing the turbulence of the molten metal.

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