目的:本研究的目的是确定哪些病理和临床因素可以区分对临床医生和病理学家有用的短螺旋体。
方法:我们根据患者的个体信息(n=113)确定了21项短波螺旋体感染的研究,并对每个物种进行了汇总分析。
结果:每种短螺旋体的病理和临床特征存在差异。感染短螺旋体感染的患者更容易出现腹泻,发烧,艾滋病毒,和免疫受损的条件。那些感染短螺旋体的患者更有可能患有固有层炎症。
结论:我们的新数据提供了对短螺旋体物种的致病机制和特定危险因素特征的潜在见解。当评估和管理患者时,这在临床上可能是有用的。
This study aims to determine what pathologic and clinical factors differentiate Brachyspira species that may be useful to clinicians and pathologists.
We identified 21 studies of Brachyspira infection with individual patient information (n = 113) and conducted a pooled analysis comparing each species.
There were differences in the pathologic and clinical profiles of each Brachyspira species. Patients infected with Brachyspira pilosicoli infection were more likely to have diarrhea, fever, HIV, and immunocompromised conditions. Those patients infected with Brachyspira aalborgi were more likely to have lamina propria inflammation.
Our novel data provide potential insights into the pathogenic mechanism(s) and the specific risk factor profile of Brachyspira species. This may be clinically useful when assessing and managing patients.