最近的证据表明,早期母体肠道菌群的变化可能会产生与精神病相关异常相关的神经生物学后果。然而,关于人类研究这个问题的研究数量有限,和临床前发现有时冲突。因此,我们进行了一项荟萃分析,以检查神经发育过程中的母体微生物群紊乱(MMD)是否会影响成年后的后代.我们发现了13项研究,从PROSPERO(#289224)上注册的策略选择的459条记录中,针对临床前研究,评估受围产期肠道菌群扰动的水坝产生的啮齿动物的行为结果。分析显示出显著的效应大小(SMD=-0.51,95%CI=-0.79至-0.22,p<.001,T2=0.54,I2=79.85%),表明MMD可能会引起成年后代的行为障碍。MMD还诱导了社交行为(SMD=-0.63,95%CI=-1.18至-0.07,p=0.011,T2=0.30,I2=76.11%)和强迫性行为(SMD=-0.68,95%CI=-0.01至-1.36,p=0.009,T2=0.25,I2=62.82%)。对于记忆和焦虑样行为,效应大小不显著或不确定,或不确定精神分裂症样和抑郁样行为。因此,实验性围产期MMD垂直传播给后代,对与精神疾病相关的行为参数产生负面影响。
Recent evidence has suggested that changes in maternal gut microbiota in early life may generate neurobiological consequences associated with psychiatric-related abnormalities. However, the number of studies on humans investigating this problem is limited, and preclinical findings sometimes conflict. Therefore, we run a meta-analysis to examine whether maternal microbiota disturbance (MMD) during neurodevelopment might affect the offspring during adulthood. We found thirteen studies, from a set of 459 records selected by strategy registered on PROSPERO (#289224), to target preclinical studies that evaluated the behavioral outcomes of the rodents generated by dams submitted to perinatal enteric microbiota perturbation. The analysis revealed a significant effect size (SMD = -0.51, 95% CI = -0.79 to -0.22, p < .001, T2 = 0.54, I2 = 79.85%), indicating that MMD might provoke behavioral impairments in the adult offspring. The MMD also induces a significant effect size for the reduction of the
sociability behavior (SMD = -0.63, 95% CI = -1.18 to -0.07, p = 0.011, T2 = 0.30, I2 = 76.11%) and obsessive-compulsive-like behavior (SMD = -0.68, 95% CI = -0.01 to -1.36, p = 0.009, T2 = 0.25, I2 = 62.82%) parameters. The effect size was not significant or inconclusive for memory and anxiety-like behavior, or inconclusive for schizophrenia-like and depressive-like behavior. Therefore, experimental perinatal MMD is vertically transmitted to the offspring, negatively impacting behavioral parameters related to psychiatric disorders.