指甲鳞状细胞癌(nSCC)是一种罕见的手和指甲恶性肿瘤。虽然皮肤癌很少影响光型IV-VI的个体,其在这些人群中的发生通常与更高的发病率和死亡率相关。本研究旨在表征临床症状,介绍,以及深色皮肤类型患者的nSCC治疗。2023年5月,对所有同行评审的PubMed和Embase进行了系统评价,涉及FitzpatrickIV-VI型个体的英语nSCC研究。大多数肿瘤位于指甲上(84%),右三指是最常见的影响(31%)。甲床(67%)的患病率高于外侧/近端指甲褶皱(33%)。诊断前症状持续时间为1个月至7年。nSCC最常采用Mohs手术治疗(38%),其次是截肢(35%)。我们的研究仅限于病例报告,因为缺乏提供每个患者种族或图像信息的大型nSCC研究。这些肿瘤通常生长缓慢,但经常被误诊,导致出现和诊断延迟。在光型IV-VI个体中提高对nSCC的认识将减少误诊,不必要的治疗,并复发。
Squamous cell carcinoma of the nail unit (nSCC) is a rare malignant tumor of the hand and nail. Although skin cancer rarely affects individuals with phototypes IV-VI, its occurrence in these groups is often associated with greater morbidity and mortality. This study aims to characterize the clinical symptoms, presentations, and treatments of nSCC in patients with darker skin types. A systematic
review of PubMed and Embase was performed in May 2023 for all peer-reviewed, English-language nSCC studies involving individuals with Fitzpatrick types IV-VI. Most tumors were located on the fingernails (84%), with the right third finger being the most frequently affected (31%). The nail bed (67%) exhibited a higher prevalence than the lateral/proximal nail folds (33%). The duration of symptoms before diagnosis ranged from 1 month to 7 years. nSCC was most commonly treated with Mohs surgery (38%), followed by amputation (35%). Our study was limited to case reports because of a lack of large nSCC studies that provide information on race or images of each patient. These tumors are generally slow-growing yet often misdiagnosed, leading to delays in presentation and diagnosis. Increased awareness about nSCC in phototype IV-VI individuals will reduce misdiagnoses, unnecessary treatment, and recurrences.