Tenofovir disoproxil fumarate (TDF) is a widely used pharmacological agent for the treatment of human immunodeficiency virus infection. While prolonged exposure to TDF has been associated with a decrease in bone mineral density (BMD) and increased fracture risk, limited discussion exists on its effects on various aspects of bone quality. This scoping review aims to provide a comprehensive overview of the impact of TDF on bone quality beyond BMD. A literature search was conducted using the PubMed and Scopus databases to identify studies investigating the effects of TDF on bone quality. Original research articles written in English, irrespective of study type or publication year, were included in the review. Seven articles met the inclusion criteria. Findings indicate that prolonged exposure to TDF adversely affects bone microarchitecture and strength, impeding fracture healing and skeletal microdamage repair. The observed effects suggest a complex interplay involving bone cell signalling, cytokines and bone remodelling processes as potential mechanisms underlying TDF\'s impact on bone quality. As a conclusion, TDF impairs bone remodelling and microarchitecture by influencing dynamic bone cell behaviour and signalling pathways. Future studies should delve deeper into understanding the intricate negative effects of TDF on bone and explore strategies for reversing these effects.

With the development of cities and population, the production of sludge is increasing annually. It has become an unavoidable challenge to achieve sludge dewatering and disposal by a cost-effective, efficient and safe process. In this work, firstly, the factors limiting sludge dewatering are reviewed in terms of moisture distribution, sludge concentration, organic matter content, electronegativity, floc strength, and extracellular polymers (EPS). Subsequently, focusing on the dewatering technology about the skeleton builder, the recent progress of it is detailed in terms of mechanism, evaluation indicators, influencing factors, and technology coupling. In addition, the impact of skeleton builders on the sludge disposal stage is concluded. Finally, the challenges faced by sludge dewatering and skeleton builders are prospected. This review will provide some theoretical basis and technical guidance for subsequent experiments and practices regarding skeleton builders.

The human skeleton displays an immense array of traits and variant features that are elements of inter-individual variability. The general assumption is that they may represent individualizing markers for the personal identification of unidentified decedents, but very few works consider them as such. This review provides an overview on the possible use of non-metric traits and skeletal variants for personal identification. The paper discusses the issues related to unquantified comparisons, then it presents a statistical approach based on frequencies of these features for identifying unknown remains. Narrowing down an initial number of 1000 papers, the core of the review is represented by 10 papers that considered non-metric traits and skeletal variants as individualizing features, according to both qualitative and quantitative assessments. Despite visual examination remains the gold-standard, more sound methods are requested to quantify the strength of a match or a mismatch. This especially applies in the wake of juridical demands, hence also satisfying the desire of prosecutors and judges to rely on a \"quantified\" risk. To this purpose, non-metric traits and skeletal variants seem to be a suitable tool to provide quantified evidence, when related frequencies are known.

Performing prescribed physical exercises during home-based rehabilitation programs plays an important role in regaining muscle strength and improving balance for people with different physical disabilities. However, patients attending these programs are not able to assess their action performance in the absence of a medical expert. Recently, vision-based sensors have been deployed in the activity monitoring domain. They are capable of capturing accurate skeleton data. Furthermore, there have been significant advancements in Computer Vision (CV) and Deep Learning (DL) methodologies. These factors have promoted the solutions for designing automatic patient\'s activity monitoring models. Then, improving such systems\' performance to assist patients and physiotherapists has attracted wide interest of the research community. This paper provides a comprehensive and up-to-date literature review on different stages of skeleton data acquisition processes for the aim of physio exercise monitoring. Then, the previously reported Artificial Intelligence (AI) - based methodologies for skeleton data analysis will be reviewed. In particular, feature learning from skeleton data, evaluation, and feedback generation for the purpose of rehabilitation monitoring will be studied. Furthermore, the associated challenges to these processes will be reviewed. Finally, the paper puts forward several suggestions for future research directions in this area.

Much research has been conducted in an attempt to decrease skeletal injuries in athletic horses. The objective of this literature review is to compile the findings of over three decades of research in this area, make practical recommendations, and describe how research can develop over the years. An initial study investigating the role of bioavailable silicon in the diets of horses in race training produced the unexpected finding of decreased bone mineral content of the third metacarpus subsequent to the onset of training. Further studies revealed this decrease to be associated with stall housing eliminating high-speed exercise, leading to disuse osteopenia. Only relatively short sprints (between 50 and 82 m) were necessary to maintain bone strength and as few as one sprint per week provided the needed stimuli. Endurance exercise without speed fails to elicit the same benefits to bone. Proper nutrition is also required for optimal bone health, but without the right exercise, strong bone cannot be maintained. Several pharmaceuticals may have unintended consequences capable of impairing bone health. Many of the factors influencing bone health in horses also exist in humans including a sedentary lifestyle, improper nutrition, and pharmaceutical side-effects.

Osteoporosis refers to excessive bone loss as reflected by the deterioration of bone mass and microarchitecture, which compromises bone strength. It is a complex multifactorial endocrine disease. Its pathogenesis relies on the presence of several endogenous and exogenous risk factors, which skew the physiological bone remodelling to a more catabolic process that results in net bone loss. This review aims to provide an overview of osteoporosis from its biology, epidemiology and clinical aspects (detection and pharmacological management). The review will serve as an updated reference for readers to understand the basics of osteoporosis and take action to prevent and manage this disease.

The grave situated in the central part of the reformed church in Silická Brezová in Slovakia contained the human skeletal remains of one individual. The aim of this study was to confirm the presence of ankylosing spondylitis on these skeletal remains. Determine the sex, age at death, stature, and ancestry of the individual by anthropological methods, and also record and identify other pathological manifestations of diseases. A macroscopic examination has been carried out, with the analysis of the palaeopathological conditions of the remains, and subsequently an X-ray and CT completed analysis. The skeleton belonged to a male of European origin, aged between 45 and 60 years at the time of death. Stature calculated from the maximal length of his femur was 163.12 ± 3.48 cm. Pathological features were identified on the many bones. Ankylosis affected almost the whole spinal cord, including the sacroiliac joints. The skeleton also presented the manifestation of many entheseal changes. Presence of the ankylosing spondylitis was confirmed by a combination of standard anthropological methods and modern diagnostic methods (X-ray and CT analysis). It is a specific disease with a prevalence between 0.1 and 1% worldwide. There is a potential for further genetic research to determine the degree of genetic relatedness with an individual living in this village who has been diagnosed with the same disease.

A century of publications in the Poultry Science journal is celebrated with Centennial papers. It is relevant, therefore, to explore trace mineral (TM) research with an emphasis on manganese and selected aspects of skeletal development. Some of the initial observations on the topic appeared in the earliest volumes of our journal. Published studies in the late 1920\'s and 1930\'s confirmed the importance of the diet and unidentified organic (i.e., vitamins) and inorganic nutrients (i.e., TM) relative to skeletal development. The early nutrition research emphasized requirement studies, the search for unknown factors to alleviate recognized deficiencies, and lastly important nutrient interactions, especially in the gut. This review will discuss TM research with an emphasis on manganese (Mn). Some of the fundamental discoveries on the mechanisms underlying embryonic and post-hatch skeletal development led directly to research directed at the role of Mn in the synthesis of the epiphyseal matrix. The TM research agenda today is considerably different with respect to all trace nutrients and is largely driven by gut health, antibiotic free production, food safety and environmental outcomes. A significant proportion of the published research over the last 2 decades has focused on the form (i.e., organic, inorganic) of a given TM relative to a given physiologic or production response under the pretext that modern commercial genotypes and production realities have changed considerably since the last NRC publication (NRC, 1994). If one closely reviews the more recent scientific literature, however, it could be argued that the term \"trace mineral requirement\" is often a misnomer. Many of the TM levels recommended or in use today are not the result of quantifiable requirement studies but are often based on efficacy comparisons with the different organic and inorganic forms of commercially available TM.

Classification of human actions is an ongoing research problem in computer vision. This review is aimed to scope current literature on data fusion and action recognition techniques and to identify gaps and future research direction. Success in producing cost-effective and portable vision-based sensors has dramatically increased the number and size of datasets. The increase in the number of action recognition datasets intersects with advances in deep learning architectures and computational support, both of which offer significant research opportunities. Naturally, each action-data modality-such as RGB, depth, skeleton, and infrared (IR)-has distinct characteristics; therefore, it is important to exploit the value of each modality for better action recognition. In this paper, we focus solely on data fusion and recognition techniques in the context of vision with an RGB-D perspective. We conclude by discussing research challenges, emerging trends, and possible future research directions.

The files of the Pathology section of F Forensic Science South Australia (FSSA) Adelaide, Australia were examined over a seven-year period from January 2013 to December 2019 for all cases where skeletal remains had been submitted for assessment. There were 150 cases comprising 79 non-human (53%), 49 traditional Australian Aboriginal (33%) and 12 Coronial (8%). The remaining cases included anatomically prepared skeletal remains or other historic remains, and four cases which were subsequently determined to be non-osseous. The large number of domestic animal bones found reflects the agricultural nature of much of the state in addition to historical urban butchering practices. The next largest category was that of indigenous remains associated with the long history of Aboriginal occupation. Established protocols ensure that this culturally-sensitive skeletal material is passed on to the appropriate traditional community leaders. This study shows the unique range of skeletal materials that is currently being forensically assessed in South Australia and the varied medicolegal implications of each category.