目的:本研究旨在探讨鼻窦浆膜黏液性错构瘤(SHs)的临床和组织病理学特征。
方法:纳入了2005年11月至2023年9月在三级医院接受治疗的8例鼻窦SH患者。此外,对已发表的文章进行了系统的审查,对文献中描述的48例SH进行分析。
结果:在我们机构接受治疗的8名患者中,4例患者的肿瘤起源于后鼻腔,而中鼻甲和中鼻道是各2例患者的主要起源。在4例中观察到炎性鼻息肉(NPs)的共存。组织病理学,4例患者表现局灶性呼吸道上皮腺瘤样错构瘤(REAH)特征,在一名患者中发现了低度发育不良。与先前文献的综合分析显示,所有病例中有46.3%起源于前鼻腔。伴有NPs和具有局灶性REAH特征的病例比例分别为20.5%和39.1%,分别。此外,表现出发育不良特征(5.4%)和复发(2.1%)的病例频率较低。值得注意的是,源自前部区域的肿瘤往往比源自后部区域的肿瘤具有更高的发育不良频率,尽管这种差异没有统计学意义(p=0.0996)。
结论:鼻窦SH患者在手术切除后显示出良好的治疗效果。经常观察到局灶性REAH特征和伴随的NP。很大一部分病例起源于前鼻腔,这些肿瘤可能表现出高度的发育不良倾向。
OBJECTIVE: This study aimed to investigate the clinical and histopathological characteristics of sinonasal seromucinous hamartomas (SHs).
METHODS: Eight patients with sinonasal SH and treated at a tertiary hospital between November 2005 and September 2023 were included. Additionally, a systematic review of published articles was conducted, analyzing 48 cases of SH described in the literature.
RESULTS: Among the eight patients treated at our institution, tumors originated from the posterior nasal cavity in four patients and middle turbinate and middle meatus were the primary origin in two patients each. Coexistence of inflammatory nasal polyps (NPs) was observed in four cases. Histopathologically, four patients exhibited focal respiratory epithelial adenomatoid hamartoma (REAH) features, and low-grade dysplasia was found in one patient. A combined analysis with previous literature revealed that 46.3% of all cases originated in the anterior nasal cavity. The proportions of cases accompanied by NPs and those with focal REAH features were 20.5% and 39.1%, respectively. Additionally, the frequencies of cases exhibiting dysplastic features (5.4%) and recurrence (2.1%) were low. Remarkably, tumors originating from the anterior region tended to have a higher frequency of dysplasia than those originating from the posterior region, although this difference was not statistically significant (p = 0.0996).
CONCLUSIONS: Patients with sinonasal SH showed favorable treatment outcomes following surgical resection. Focal REAH features and accompanying NPs were frequently observed. A substantial proportion of cases originate in the anterior nasal cavity, and these tumors may exhibit a high tendency for dysplasia.