Nanoplastics (NPs) pose great challenges to soil-groundwater systems. This study investigated the transport and retention of self-synthesized 0.5-μm polystyrene NPs with different shapes using column experiments. The regular NPs were with spherical shapes, while the irregular NPs were with toroid-like shapes. The toroid-like shapes were the irregular shapes (with low aspect ratio) which have not been studied yet. The explorations were carried out in both 5-25 mM NaNO3 and 1-10 mM Ca(NO3)2 solutions. Both breakthrough curves (BTCs) and retained profiles (RPs) were monitored. Our findings uncovered a clear disparity in the transport of irregular and regular NPs, with irregular particles exhibiting lower transport ability compared to the regular ones. For example, the average breakthrough plateaus of the regular and irregular NPs were ∼0.9 and ∼0.5, respectively, in 10 mM NaNO3. In-depth theoretical analysis indicated that the lower XDLVO interaction energy barrier between the irregular NPs and quartz sand was one factor, and the greater margination of irregular NPs on quartz sand, as verified by the numerical simulation, was another factor leading to the decreased transport and increased retention of the irregular NPs. The obtained results highlighted the significance of considering particle shape in future modelling and predicting the fate of NPs in real environmental circumstances.

OBJECTIVE: To assess the ability of the pressure gradient between breast lesions and adjacent normal tissue estimated by 3D subharmonic-aided pressure estimation (SHAPE) to characterize indeterminate breast lesions.
METHODS: This prospective study enrolled patients scheduled for ultrasound-guided needle biopsies of a breast lesion. Before the biopsy, 3D SHAPE data were collected from the breast lesion during the infusion of an ultrasound contrast agent (Definity) as well as after clearance of the agent. Direct, invasive pressure measurements in the lesion and adjacent normal tissue were then obtained using an intracompartmental pressure monitoring system (C2DX) before tissue sampling as part of the biopsy procedure. The mean SHAPE gradient and invasive measurement gradient between the lesion and adjacent normal tissue were compared to the biopsy results. The SHAPE gradients were also compared to the invasive pressure gradients.
RESULTS: There were 8 malignant and 13 benign lesions studied. The SHAPE gradients and invasive pressure gradients were significantly different between the benign and malignant lesions (2.86 ± 3.24 vs. -0.03 ± 1.72 a.u.; p = 0.03 and 9.9 ± 8.5 vs. 20.9 ± 8.0 mmHg; p = 0.008, respectively). The area under the curves, specificities, and sensitivities for detecting malignancy by SHAPE gradients and invasive pressure gradients were 0.79 and 0.88, 77% and 92%, and 88% and 50%, respectively. A weak negative correlation was found between the SHAPE and invasive pressure gradients (r = -0.2).
CONCLUSIONS: The pressure gradient between a breast lesion and adjacent normal tissue estimated by 3D SHAPE shows potential for characterizing indeterminate breast lesions.

Crossmodal correspondences, the tendency for a sensory feature / attribute in one sensory modality (either physically present or merely imagined), to be associated with a sensory feature in another sensory modality, have been studied extensively, revealing consistent patterns, such as sweet tastes being associated with pink colours and round shapes across languages. The present research explores whether such correspondences are captured by ChatGPT, a large language model developed by OpenAI. Across twelve studies, this research investigates colour/shapes-taste crossmodal correspondences in ChatGPT-3.5 and -4o, focusing on associations between shapes/colours and the five basic tastes across three languages (English, Japanese, and Spanish). Studies 1A-F examined taste-shape associations, using prompts in three languages to assess ChatGPT\'s association of round and angular shapes with the five basic tastes. The results indicated significant, consistent, associations between shape and taste, with, for example, round shapes strongly associated with sweet/umami tastes and angular shapes with bitter/salty/sour tastes. The magnitude of shape-taste matching appears to be greater in ChatGPT-4o than in ChatGPT-3.5, and ChatGPT prompted in English and Spanish than ChatGPT prompted in Japanese. Studies 2A-F focused on colour-taste correspondences, using ChatGPT to assess associations between eleven colours and the five basic tastes. The results indicated that ChatGPT-4o, but not ChatGPT-3.5, generally replicates the patterns of colour-taste correspondences that have previously been observed in human participants. Specifically, ChatGPT-4o associates sweet tastes with pink, sour with yellow, salty with white/blue, bitter with black, and umami with red across languages. However, the magnitude/similarity of shape/colour-taste matching observed in ChatGPT-4o appears to be more pronounced (i.e., having little variance, large mean difference), which does not adequately reflect the subtle nuances typically seen in human shape/colour-taste correspondences. These findings suggest that ChatGPT captures colour/shapes-taste correspondences, with language- and GPT version-specific variations, albeit with some differences when compared to previous studies involving human participants. These findings contribute valuable knowledge to the field of crossmodal correspondences, explore the possibility of generative AI that resembles human perceptual systems and cognition across languages, and provide insight into the development and evolution of generative AI systems that capture human crossmodal correspondences.

OBJECTIVE: The objective of this study was to investigate the subharmonic response of Lumason (also known as SonoVue; Bracco, Milan, Italy) to static and dynamic ambient pressures, with a direct comparison to Sonazoid (GE HealthCare, Oslo, Norway) and Definity (Lantheus Medical Imaging, MA, USA). The subharmonic responses of contrast agents can be exploited to perform subharmonic-aided pressure estimation.
METHODS: The subharmonic response of each ultrasound contrast agent was evaluated in both a static and dynamic tank using a commercially available Logiq E10 clinical ultrasound scanner (GE HealthCare) equipped with subharmonic imaging (SHI) and an acoustic power-optimization algorithm. A C1-6 curvilinear array that transmits at 2.5 MHz and receives at 1.25 MHz in SHI mode was used to acquire the subharmonic signals. Data was transferred offline into MATLAB (MathWorks) to perform linear regression analysis and statistical testing for significance of the slopes (i.e., agent sensitivity).
RESULTS: Sonazoid and Definity showed an inverse linear dependency between subharmonic signal and hydrostatic pressure at all pressure ranges (static and dynamic) tested, with maximum sensitivity under 50 mmHg in the static tank (-0.190 and -0.194 dB/mmHg for Sonazoid and Definity, respectively). Lumason exhibited a tri-phasic subharmonic behavior, beginning with a linear trend from 0 to 90 mmHg (sensitivity = 0.069 dB/mmHg), followed by a plateau from 100 to 130 mmHg, and an inverse linear trend from 140 to 200 mmHg (sensitivity = -0.137 dB/mmHg).
CONCLUSIONS: The subharmonic response of Lumason is tri-phasic and differs from Sonazoid and Definity. Further investigation is needed to solidify understanding of the subharmonic behavior of Lumason to identify its usefulness for subharmonic-aided pressure estimation.

Abatus is a genus of irregular brooding sea urchins to the Southern Ocean. Among the 11 described species, three shared morphological traits and present an infaunal lifestyle in the infralittoral from the Subantarctic province; A. cavernosus in Patagonia, A. cordatus in Kerguelen, and A. agassizii in Tierra del Fuego and South Shetlands. The systematic of Abatus, based on morphological characters and incomplete phylogenies, is complex and largely unresolved. This study evaluates the shape variation among these species using geometric morphometrics analysis (GM). For this, 72 individuals from four locations; South Shetlands, Kerguelen, Patagonia, and Falklands/Malvinas were photographed, and 37 landmarks were digitized. To evaluate the shape differences among species, a principal component analysis and a Procrustes ANOVA were performed. Our results showed a marked difference between the Falklands/Malvinas and the other localities, characterized by a narrower and more elongated shape and a significant influence of location in shape but not sex. Additionally, the effect of allometry was evaluated using a permutation test and a regression between shape and size, showing significant shape changes during growth in all groups. The possibility that the Falklands/Malvinas group shows phenotypic plasticity or represents a distinct evolutionary unit is discussed. Finally, GM proved to be a powerful tool to differentiate these species, highlighting its utility in systematic studies.

The Delboeuf illusion occurs when two circles (test figures) of equal radius are placed side by side and surrounded by concentric circles (inducers) of varying radii, resulting in the test figure being misestimated depending on the size of the surrounding inducer. This study conducted three experiments to explore the impact of shape and the contour attraction and parallel attraction on the Delboeuf illusion for different shapes. In Experiment 1 (n = 64), the test figures remained as circles while the inducers varied in shape. Experiment 2 (n = 64) involved simultaneous changes in the shape of both the test figures and the inducers. Experiment 3 (n = 64) replicated Experiment 2, with the exception that the areas of the inducers were equal and the distances between the inducers and the test figures were also equal. We conclude that the shape of the inducer and the test figure had an impact on the visual size perception, and in the magnitude of the Delboeuf illusion, varied depending on contour attraction. Configurations with circles or shapes resembling circles exhibit contour attraction, while configurations with shapes possessing longer parallel lines shift toward parallel attraction, both attractions enhance the perceived magnitude of the Delboeuf illusion.

Activated carbon (AC) has been widely used in volatile organic compounds (VOCs) treatment of industrial exhaust gases. Rather than modifying specific pore size distributions and surface properties, altering the shape of AC offers a more feasible approach to enhance its adsorption performance. This study investigates the adsorption-desorption performance of two different shaped ACs with highly similar properties for the removal of VOCs. The clover-shaped AC (CSAC) has a 27.46% lower internal void fraction and a 39.10% higher external void fraction compared to cylindrical AC (CAC), resulting in denser packing and longer contact time with VOCs. Adsorption experiments showed the CSAC has 40% longer adsorption breakthrough (BT) times for ethanol, ethyl acetate, and n-hexane on average, and 20% higher saturation adsorption capacity per unit volume. CSAC also has higher partition coefficients, with the highest values for ethanol, ethyl acetate, and n-hexane being 0.0187, 0.0382, and 0.0527 mol kg-1·Pa-1, respectively. The desorption process for selected VOCs is non-spontaneous and endothermic. Optimal desorption conditions were identified as an inlet space velocity of 3535 h-1, a desorption temperature of 150 °C, and a pulsed inlet method. To investigate the possibility of the application of CSAC in real-world scenarios, xylene was chosen as a representative industrial VOC. Results showed CSAC has 20% higher BT time and saturation adsorption capacity for xylene compared to CAC under different bed heights. The desorption efficiency for xylene on both ACs is below 40%. With increasing xylene inlet concentration, the mass transfer zone (MTZ) height initially increases but stabilizes beyond 1704 mg m-3. At identical bed heights, the MTZ height of CSAC is 29% shorter than CAC, indicating a higher bed utilization efficiency.

This study assessed the effect of boning processing method (hot vs. cold) on pork belly morphological and mechanical traits and the evolution of these traits during refrigerated storage postmortem (PM). A total of 14 crossbred pigs were slaughtered and their carcasses and bellies processed under two conditions: hot boning (n = 14, right sides of carcasses cut immediately after slaughter) and cold boning (n = 14, left sides of carcasses cut 24 h PM). Morphological and mechanical evaluations were made at 1-, 5-, 24- and 48-h PM on the hot-boned bellies, and at 24 and 48 h on the cold-boned ones. Compared to the cold-boned bellies, the hot-boned ones were shorter, wider and thicker (P < 0.01), with greater firmness (flop distance and angle) (P < 0.001) and cohesiveness (skin-fat separation) (P < 0.05 in the dorsal and central sections). At 48 h PM, hot-boned bellies had a thicker skin (P < 0.001) and softer subcutaneous fat in the dorsal-cranial and central sections (finger scores and compression textural test) (P < 0.05). Morphological and mechanical traits for hot-boned bellies confirmed an intense shortening and hardening (increased firmness and cohesiveness), and a slight yield loss from 1 to 24 h PM. From 24 to 48 h PM, there was a certain flattening in hot-boned bellies that was associated with a slight softening (reduced firmness). Although a larger sample may be needed to corroborate these findings, they demonstrate the impact of carcass processing method and refrigerated storage time on belly quality. This may be useful for the pork industry for obtaining the desired type of belly.

Soil erosion is a critical process that leads to landscape degradation, compromising soil fertility and ecosystem functions. Forest ecosystems, with their intricate characteristics, play a pivotal role in mitigating soil erosion and providing soil retention ecosystem services (SRES). This study explores the impact of forest patch thresholds and critical points on soil erosion rates, focusing on 401 catchments in Poland using generalised additive models to identify thresholds and critical points in forest patches. Landscape metrics were applied to measure landscape structure, including shape, fractal dimension, contiguity, related circumscribing circles, and perimeter-area ratio indexes. These metrics, along with slope, rainfall, organic carbon content, water content, and clay ratio variables, were considered dependent variables in the models. The developed models have demonstrated reliable performance in estimating soil erosion rates, with a significant deviation explained from 80.5 to 81.1 for coniferous forest patches, 79.1 to 80.1 for broad-leave forest patches, and 80.9 to 81.4 for mixed forest patches at p < 0.05. In broad-leaved forests, three thresholds are identified in the shape index, which influence soil erosion rates in a complex manner. For coniferous forests, thresholds in the perimeter area ratio, related circumscribing circles, and contiguity indexes exhibit nonlinear relationships with soil erosion rates. Mixed forests show two thresholds in the related circumscribing circle and one in the fractal dimension index, affecting soil erosion rates differently. This research contributes significantly to understanding the interplay between forest patch shapes and soil erosion rates, providing decision support for land use planning. The identified thresholds and critical points offer valuable tools to enhance sustainable landscape functionality, emphasizing the importance of considering forest landscape structure in preserving soil retention ecosystem services.

The branched architecture of neuronal dendrites is a key factor in how neurons form ordered networks and discoveries continue to be made identifying proteins and protein-protein interactions that direct or execute the branching and extension of dendrites. Our prior work showed that the molecular scaffold Pdlim5 and delta-catenin, in conjunction, are two proteins that help regulate the branching and elongation of dendrites in cultured hippocampal neurons and do so through a phosphorylation-dependent mechanism triggered by upstream glutamate signaling. In this report we have focused on Pdlim5\'s multiple scaffolding domains and how each contributes to dendrite branching. The three identified regions within Pdlim5 are the PDZ, DUF, and a trio of LIM domains; however, unresolved is the intra-molecular conformation of Pdlim5 as well as which domains are essential to regulate dendritic branching. We address Pdlim5\'s structure and function by examining the role of each of the domains individually and using deletion mutants in the context of the full-length protein. Results using primary hippocampal neurons reveal that the Pdlim5 DUF domain plays a dominant role in increasing dendritic branching. Neither the PDZ domain nor the LIM domains alone support increased branching. The central role of the DUF domain was confirmed using deletion mutants in the context of full-length Pdlim5. Guided by molecular modeling, additional domain mapping studies showed that the C-terminal LIM domain forms a stable interaction with the N-terminal PDZ domain, and we identified key amino acid residues at the interface of each domain that are needed for this interaction. We posit that the central DUF domain of Pdlim5 may be subject to modulation in the context of the full-length protein by the intra-molecular interaction between the N-terminal PDZ and C-terminal LIM domains. Overall, our studies reveal a novel mechanism for the regulation of Pdlim5\'s function in the regulation of neuronal branching and highlight the critical role of the DUF domain in mediating these effects.