背景:衰老是心血管事件的独立危险因素。它促进血管功能障碍,这与心血管疾病(CVD)的危险因素有关。运动可以调节血管功能参数,但对不同训练方式的影响知之甚少(有氧,阻力,并结合)对老年人的内皮功能和动脉僵硬度。
方法:这项系统综述研究将包括从电子数据库MEDLINE(PubMed)中选择的随机对照试验(RCT),科克伦,LILACS,EMBASE,和WebofScience。我们将遵循PRISMA指南和PICOS框架。涉及男性和女性老年人(≥60岁)的研究,有或没有有氧合并症,阻力,和/或与对照组(无运动)相比的联合训练将是合格的。我们将使用Cochrane偏差风险2(RoB2)工具来评估个体研究的质量和等级,以评估证据的强度。统计分析将使用RStudioforWindows(v1.3.959)使用R包元进行。
结论:涉及老年人研究数据的系统评价和荟萃分析将加深我们对该人群血管适应运动训练的理解。它可以为医疗服务提供者如何改善老年人的患者管理和预防心血管事件提供新的见解。
背景:PROSPERO42021275451。
BACKGROUND: Aging is an independent risk factor for cardiovascular events. It promotes vascular dysfunction which is associated with risk factors for cardiovascular diseases (CVDs). Exercise can modulate vascular function parameters, but little is known about the effects of different modalities of training (aerobic, resistance, and combined) on endothelial function and arterial stiffness in older adults.
METHODS: This systematic
review study will include randomized controlled trials (RCTs) selected from the electronic databases MEDLINE (PubMed), Cochrane, LILACS, EMBASE, and Web of Science. We will follow the PRISMA guidelines and PICOS framework. Studies involving both male and female older adults (≥60 years old) with or without comorbidities undergoing aerobic, resistance, and/or combined training compared to a control group (no exercise) will be eligible. We will use the Cochrane Risk of Bias 2 (RoB 2) tool to evaluate the quality of individual studies and GRADE to assess the strength of evidence. Statistical analyses will be conducted with RStudio for Windows (v1.3.959) using R package meta.
CONCLUSIONS: A systematic
review and meta-analysis involving data from studies of older adults would deepen our understanding of vascular adaptations to exercise training in this population. It could provide new insights into how health providers can improve patient management and prevention of cardiovascular events in older adults.
BACKGROUND: PROSPERO 42021275451.