良性B细胞前体的光谱，被称为血液酮(HGs)，显示了与其恶性对应物即B淋巴母细胞(BLB)的显著形态学和免疫表型重叠。这导致在评估HG具有生理优势的病例时的诊断困境，并且在B细胞急性淋巴细胞白血病中可测量的残留疾病评估中也提出了重大挑战。因此,各种免疫表型标记的表达模式被认为是鉴定和描绘来自BLB的HG的最重要工具。然而,通过流式细胞术免疫表型分析进行B细胞区室评估的某些方面及其在临床情景中的相关性尚待精确定义.这篇综述基于对文献的全面回顾和对内部数据的评估，总结了目前关于HG的流式细胞术数据及其与BLB的区别。此外，它侧重于额外的分析工具的效用，即，雷达图，可全面表示B细胞区室的各种子集及其与BLB的区别。
■在线版本包含补充材料，可在10.1007/s12288-023-01696-5获得。
The spectrum of benign B-cell precursors, known as hematogones (HGs), shows a significant morphological and immunophenotypic overlap with their malignant counterpart i.e. B-lymphoid blasts (BLBs). This results in a diagnostic dilemma in assessment of cases wherein there is a physiological preponderance of HGs and also poses a significant challenge in measurable residual disease assessment in B-cell acute lymphoblastic leukaemia. Consequently, expression patterns of various immunophenotypic markers are considered the most important tool in identification and delineation of HGs from BLBs. However, certain aspects of B-cell compartment evaluation by flow cytometric immunophenotyping and its relevance in clinical scenarios is yet to be defined precisely. This
review summarizes current flowcytometric data on HGs and its discrimination from BLBs based on thorough
review of literature and evaluation of in-house data. Furthermore, it focuses on the utility of an additional analytical tool i.e., radar plot for a comprehensive representation of various subsets of the B-cell compartment and their differentiation from BLBs.
UNASSIGNED: The online version contains supplementary material available at 10.1007/s12288-023-01696-5.
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